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  • Pneumonia hospitalizations in the elderly in Portugal between 1998-2015
    Publication . Kislaya, Irina; Sousa-Uva, Mafalda; Gómez, Verónica; Nunes, Baltazar; Rodrigues, Ana Paula
    We performed ecological study using data on hospital admissions of individuals aged 65 or more years old with principal diagnosis coded according ICD-9-CM as 480-487 or 510 for all-cause pneumonia (ACP) and 481 for pneumococcal pneumonia (PP) , respectively. Between 1998 and 2015 of all hospitalizations of older adults 7.6% were by ACP and 0.4% by PP. In 1998 the admission rates for ACP and PP were of 111.7/10000 and 6.0/10000 for male and 63.7/10000 and 3.5/10000 for female, respectively. In 2015 the admission rates were 192.3/10000 and 5.0/10000 for male and 133.6/10000 and 3.3/10000 for female. The hospitalization rates for pneumonia were high in Portugal. All-cause pneumonia hospitalization rates for individuals aged 65 or more years increased in 18 year under study, the different trend was verified for pneumococcal pneumonia hospitalizations.
    2017-09-06Documento de conferência Acesso restrito Ver mais
  • Next Generation Sequencing Improves Mitochondrial Diseases Diagnosis
    Publication . Nogueira, Célia; Vilarinho, Laura; Pereira, Cristina; Silva, Lisbeth; Vieira, Luis; Leão Teles, Elisa; Rodrigues, Esmeralda; Campos, Teresa; Janeiro, Patrícia; Costa, Claúdia; Gaspar, Ana; Soares, Gabriela; Bandeira, Anabela; Martins, Esmeralda; Magalhães, Marina; Sequeira, Sílvia; Vieira, José Pedro; Santos, Helena
    Objectives: The overall aim of our research project was to develop a Next Generation Sequencing strategy to identify nuclear disease causing-mutations in patients suspicious of mitochondrial disorders but without molecular etiology.
    2017-09-06Documento de conferência Acesso aberto Ver mais
  • Environmental stress is the major cause of transcriptomic and proteomic changes in GM and non-GM plants
    Publication . Batista, Rita; Fonseca, C.; Planchon, Sébastien; Negrão, Sónia; Renaut, Jenny; Oliveira, Margarida
    The approval of genetically modified (GM) crops is preceded by years of intensive research to demonstrate safety to humans and environment. We recently showed that in vitro culture stress is the major factor influencing proteomic differences of GM vs. non-GM plants. This made us question the number of generations needed to erase such “memory”. We also wondered about the relevance of alterations promoted by transgenesis as compared to environment-induced ones. Here we followed three rice lines (1-control, 1-transgenic and 1-negative segregant) throughout eight generations after transgenesis combining proteomics and transcriptomics, and further analyzed their response to salinity stress on the F6 generation. Our results show that: (a) differences promoted during genetic modification are mainly short-term physiological changes, attenuating throughout generations, and (b) environmental stress may cause far more proteomic/transcriptomic alterations than transgenesis. Based on our data, we question what is really relevant in risk assessment design for GM food crops.
    2017-09-06Artigo científico Acesso aberto Ver mais