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  • The histopathological timeframe of Hyalomma lusitanicum infestation development on bovines
    Publication . Zúquete, S.T.; Carvalho, S.; Santos-Silva, M.M.; Santos, A.S.; Fonseca, I.P.; Correia, J.; Cardoso, L.A.
    Ticks are competent vectors of both animal and human pathogens. Hard ticks secure their meals by attaching to a host for several days. Even though some animals are capable of acquiring some resistance to ticks after several infestations, tick attachment to naïve cattle often result in skin lesions because host inflammatory reaction is not enough to induce efficient responses capable of leading to ticks skins detachment. In order to characterize the recruitment of local inflammatory responses, two Holstein-Frisea females were infested with laboratory reared Hyalomma lusitanicum adult ticks.
    2016-05-20Documento de conferência Acesso restrito Ver mais
  • Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
    Publication . Martins, M.; Boavida, J.M.; Raposo, J.F.; Froes, F.; Nunes, Baltazar; Ribeiro, R.T.; Macedo, M.P.; Penha-Gonçalves, C.
    Objectives: This study aimed to estimate the prevalence of diabetes mellitus (DM) in hospitalized patients with community-acquired pneumonia (CAP) and its impact on hospital length of stay and inhospital mortality. Research design and methods: We carried out a retrospective, nationwide register analysis of CAP in adult patients admitted to Portuguese hospitals between 2009 and 2012. Anonymous data from 157 291 adult patients with CAP were extracted from the National Hospital Discharge Database and we performed a DM-conditioned analysis stratified by age, sex and year of hospitalization. Results: The 74 175 CAP episodes that matched the inclusion criteria showed a high burden of DM that tended to increase over time, from 23.7% in 2009 to 28.1% in 2012. Interestingly, patients with CAP had high DM prevalence in the context of the national DM prevalence. Episodes of CAP in patients with DM had on average 0.8 days longer hospital stay as compared to patients without DM ( p<0.0001), totaling a surplus of 15 370 days of stay attributable to DM in 19 212 admissions. In-hospital mortality was also significantly higher in patients with CAP who have DM (15.2%) versus those who have DM (13.5%) ( p=0.002). Conclusions: Our analysis revealed that DM prevalence was significantly increased within CAP hospital admissions, reinforcing other studies’ findings that suggest that DM is a risk factor for CAP. Since patients with CAP who have DM have longer hospitalization time and higher mortality rates, these results hold informative value for patient guidance and healthcare strategies.
    2016-05-20Artigo científico Acesso aberto Ver mais