Browsing by Author "Sokhatska, Oksana"
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- Cytokine gene polymorphisms in Pigeon Breeder's Disease expressionPublication . Freitas, Cláudia; Lima, Bruno; Martins, Natália; Melo, Natália; Mota, Patrícia; Novais-Bastos, Hélder; Alves, Helena; Sokhatska, Oksana; Delgado, Luís; Morais, AntónioBackground: Exaggerated immunological response to repeated inhalation of organic or chemical dusts may lead to Hypersensitivity Pneumonitis among sensitized individuals. Only a few exposed individuals became ill and disease expression pattern is highly variable which suggest that genetic factors may play a role. Aim: To investigate interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-6, transforming growth factor (TGF)-ß, and IL-10 gene polymorphisms in a cohort of pigeon breeder's disease (PBD) patients in comparison with exposed but healthy controls and the association with different patterns of disease. Methods: We evaluated 40 PBD patients and 70 exposed controls. IFN-γ, TNF-α, IL-6, TGF-ß, and IL-10 polymorphisms were determined by polymerase chain reaction-sequence specific primer amplification. Results: Polymorphism analysis of IFN-γ, TNF-α, IL-6, TGF-ß, and IL-10 genotypes and allele frequencies showed no differences between patients and controls. IFN-γ T/T genotype frequency was increased among patients with chronic presentation (RR=2.33, p=0.047) compared with those with acute/subacute presentation. Also, chronic presenting patients had an increased frequency of IFN-γ T allele (50% vs 22.5%, RR=1.76, p=0.011). No differences were found in TNF-α, IL-6, TGF-ß, and IL-10 genotypes neither allelic frequencies between both groups of patients. IL-6 C/C genotype was more frequent in patients who showed chronic evolution (RR=2.54, p=0.017), when comparing with patients with disease resolution. Conclusion: IFN-γ T/T and the IL-6 C/C genotypes seem to play a role in HP expression due to avian exposure, as their frequencies are increased in chronic presentations or in those with chronic evolution one year after the initial diagnosis, respectively. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (3): e2020004).
- Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)Publication . Silva, Diana; Moreira, Rita; Sokhatska, Oksana; Beltrão, Marília; Montanha, Tiago; Garcia-Larsen, Vanessa; Villegas, Rodrigo; Severo, Milton; Pizarro, Andreia; Pinto, Mariana; Martins, Carla; Duarte, Ana; Delgado, Luís; Rufo, João; Paciência, Inês; Teixeira, João Paulo; Costa, Carla; Moreira, Pedro; Carvalho, Joana; Moreira, AndréThe effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status.