Browsing by Author "Shuurman, N."
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- Specific serology for emerging human coronaviruses by protein microarrayPublication . Reusken, C.; Mou, H.; Godeke, G. J.; Hoek, L.; Meyer, B.; Müller, M. A.; Haagmans, B.; Sousa, R.; Shuurman, N.; Rottier, P.; Osterhaus, A.; Drosten, C.; Bosch, B. J.; Koopmans, M.We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology. The assay uses the S1 receptor-binding subunit of the spike protein of hCoV-EMC and SARS-CoV as antigens. The assay has been validated extensively using putative cross-reacting sera of patient cohorts exposed to the four common hCoVs and sera from convalescent patients infected with hCoV-EMC or SARS-CoV.