Browsing by Author "Preter, Katleen de"
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- High frequency of subclonal ALK mutations in high risk neuroblastoma patients. A SIOPEN studyPublication . Bellini, Angela; Bernard, Virginie; Lapouble, Eve; Clement, Nathalie; Pierron, Gaelle; Ambros, Inge M.; Preter, Katleen de; Van Roy, Nadine; Vicha, Ales; Combaret, Valérie; Betts, David; Jeison, Marta; Avigad, Smadar; Morini, Martina; Varesio, Luigi; Marques9, Barbara; Muhlethaler, Annick; Noguera, Rosa; Berbegall, Ana; Mora, Jaime Font de; Ambros, Peter F.; Ladenstein, Ruth; Valteau-Couanet, Dominique; Michon, Jean; Delattre, Olivier; Bown, Nick; Tweddle, Deborah; Schleiermache, GudrunIntroduction: In neuroblastoma (NB), activating ALK receptor tyrosine kinase point mutations are detected in 8–10% at diagnosis using conventional sequencing. To determine the potential occurrence and the prognostic impact of ALK mutations in a series of high risk NB patients we studied ALK variation frequencies using targeted deep sequencing in samples of patients enrolled in the SIOPEN HR-NBL01 study