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Browsing by Author "Plachouras, Diamantis"

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  • Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
    Publication . Cassini, Alessandro; Högberg, Liselotte Diaz; Plachouras, Diamantis; Quattrocchi, Annalisa; Hoxha, Ana; Simonsen, Gunnar Skov; Colomb-Cotinat, Mélanie; Kretzschmar, Mirjam E.; Devleesschauwer, Brecht; Cecchini, Michele; Ouakrim, Driss Ait; Oliveira, Tiago Cravo; Struelens, Marc J.; Suetens, Carl; Monnet, Dominique L.; Strauss, Reinhild; Mertens, Karl; Struyf, Thomas; Catry, Boudewijn; Latour, Katrien; Ivanov, Ivan N.; Dobreva, Elina G.; Tambic Andraševic, Arjana; Soprek, Silvija; Budimir, Ana; Paphitou, Niki; Žemlicková, Helena; Schytte Olsen, Stefan; Wolff Sönksen, Ute; Märtin, Pille; Ivanova, Marina; Lyytikäinen, Outi; Jalava, Jari; Coignard, Bruno; Eckmanns, Tim; Abu Sin, Muna; Haller, Sebastian; Daikos, George L.; Gikas, Achilleas; Tsiodras, Sotirios; Kontopidou, Flora; Tóth, Ákos; Hajdu, Ágnes; Guólaugsson, Ólafur; Kristinsson, Karl G.; Murchan, Stephen; Burns, Karen; Pezzotti, Patrizio; Gagliotti, Carlo; Dumpis, Uga; Liuimiene, Agne; Perrin, Monique; Borg, Michael A.; de Greeff, Sabine C.; Monen, Jos C.M.; Koek, Mayke B.G.; Elstrøm, Petter; Zabicka, Dorota; Deptula, Aleksander; Hryniewicz, Waleria; Caniça, Manuela; Nogueira, Paulo Jorge; Fernandes, Paulo André; Manageiro, Vera; Popescu, Gabriel A.; Serban, Roxana I.; Schréterová, Eva; Litvová, Slavka; Štefkovicová, Mária; Kolman, Jana; Klavs, Irena; Korošec, Aleš; Aracil, Belén; Asensio, Angel; Pérez-Vázquez, María; Billström, Hanna; Larsson, Sofie; Reilly, Jacqui S.; Johnson, Alan; Hopkins, Susan
    Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted life-years (DALYs). Methods: We estimated the incidence of infections with 16 antibiotic resistance–bacterium combinations from European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015 data that was country-corrected for population coverage. We multiplied the number of bloodstream infections (BSIs) by a conversion factor derived from the European Centre for Disease Prevention and Control point prevalence survey of health-care-associated infections in European acute care hospitals in 2011–12 to estimate the number of non-BSIs. We developed disease outcome models for five types of infection on the basis of systematic reviews of the literature. Findings: From EARS-Net data collected between Jan 1, 2015, and Dec 31, 2015, we estimated 671 689 (95% uncertainty interval [UI] 583 148–763 966) infections with antibiotic-resistant bacteria, of which 63·5% (426 277 of 671 689) were associated with health care. These infections accounted for an estimated 33 110 (28 480–38 430) attributable deaths and 874 541 (768 837–989 068) DALYs. The burden for the EU and EEA was highest in infants (aged <1 year) and people aged 65 years or older, had increased since 2007, and was highest in Italy and Greece. Interpretation: Our results present the health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases.
    2018-11-05Journal article Open access Show more
  • Large increase in bloodstream infections with carbapenem-resistant Acinetobacter species during the first 2 years of the COVID-19 pandemic, EU/EEA, 2020 and 2021
    Publication . Kinross, Pete; Gagliotti, Carlo; Merk, Hanna; Plachouras, Diamantis; Monnet, Dominique L; Högberg, Liselotte Diaz; EARS-Net Study Group; EARS-Net Study Group participants
    Bloodstream infections (BSIs) with Acinetobacter species commonly have poor outcomes, especially in intensive care unit (ICU) patients [1]. Acinetobacter spp. is intrinsically resistant to many antimicrobials, and additional acquired resistance further complicates the treatment of serious infections in already vulnerable patient groups. Recent data from the European Antimicrobial Resistance Surveillance Network (EARS-Net) show a large and statistically significant increase in reports of Acinetobacter spp. BSIs in the European Union (EU) and European Economic Area (EEA) during the period from 2017 to 2021 [2]. Most of this increase occurred in 2020 and 2021, the first years of the coronavirus disease (COVID-19) pandemic. Here we further explore this trend in a subset of data from laboratories that continuously reported data during that period.
    2022-11-17Journal article Open access Show more