Browsing by Author "Martins, Carla Teles"
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- Exposure of Portuguese population to mycotoxins: the human biomonitoring approachPublication . Martins, Carla Teles; Nunes, Carla; Alvito, PaulaIntroduction: Mycotoxins are food contaminants with several health outcomes such as carcinogenic, estrogenic, immunotoxic, nephrotoxic and teratogenic effects. The present Thesis aimed to assess the exposure of the Portuguese population to mycotoxins through a human biomonitoring approach. Materials and Methods: Under the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016), 94 participants provided urine samples for the determination of 42 mycotoxins’ urinary biomarkers. Probable daily intake, hazard quotient and the associated burden of disease were estimated. Through a modelling approach, the exposure to zearalenone, alternariol and deoxynivalenol was estimated for a representative sample of the Portuguese population (n=5811). Results and Discussion: Results revealed the exposure of Portuguese population to aflatoxins, zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1. Risk characterization showed a potential concern since the reference intake values were exceeded by some of the participants. The exposure to aflatoxins was estimated to correspond to 172.8 Disability-Adjusted Life Years for the Portuguese population. Conclusions: The obtained data confirmed mycotoxins as part of the human exposome of the Portuguese population. Through the application of modelling tools, evidence based data was generated and it can be concluded that exposure may represent a concern for some population groups. These data are crucial to perform a more realistic risk assessment, contributing to more effective preventive measures for health protection of the Portuguese population.
- Integração Profissional em Análises Clínicas e Saúde PúblicaPublication . Martins, Carla TelesAtividades do INSA, IP no âmbito das Análises Clínicas e Saúde Pública.