Percorrer por autor "Koutsodimou, Aglaia"
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- Innovating in the exposure and risk assessment of chemical contaminants – exploring synergies with the European PARC ProjectPublication . Silva, Maria João; Koutsodimou, Aglaia; Namorado, Sónia; Dessipri, Eugenia; Alygisakis, Nikiforos; Rousselle, Christophe; Sanders, PascalThe prevalence of many human diseases can be drastically reduced through the identification and prevention of environmental risk factors. This fact constitutes a strong incentive to innovate in the exposure and hazard assessment of chemicals, through all available knowledge and technologies, towards a next-generation risk assessment (NGRA). The European Partnership for the Assessment of Risks from Chemicals (PARC, 2022 – 2029) coordinated by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), brings together around 200 partners from all Europe and three European Agencies, with the common goal of strengthening research and increasing the capacity for innovation in risk assessment, to protect human health and the environment. PARC is organized in three main pillars; i) establishment of a high level network at the interface of science and policy, setting the science-policy agenda and developing synergies collaboration and awareness; ii) implementation of Research & Innovation towards NGRA , comprising the fields of exposure and monitoring, hazard assessment, innovation in regulatory risk assessment and concepts and toolboxes; iii) development of capacities and platforms, to ensure FAIR data production and to develop infrastructures and human capacities. PARC was built on lessons learned and knowledge acquired in other initiatives, e.g., the Human Biomonitoring Initiative for Europe (HBM4EU) but intends to go further and use a more holistic approach through the development of tools and methods that will enable the integration of all sources and routes of exposure to chemical contaminants and by targeting human and environmental health. Several substances groups have been prioritised for study, including heavy metals, bisphenol A analogues, pesticides, and mycotoxins. Taking advantage of established and innovative tools and technologies, PARC also expects to increase the effi ciency of in vitro toxicity testing while reducing the use of animals. The development of Adverse Outcome Pathways will set the biological framework to enable the development of integrated approaches to testing and assessment for regulatory decision-making. This will support the implementation of preventive measures, interventions, or new policies, to better protect public health. To boost its impact, a strategy for the communication and dissemination of PARC outcomes, targeted to diff erent end-users, has been established. Furthermore, PARC offers a unique opportunity to foster synergies and establish effective collaborations with other relevant scientifi c and/or regulatory initiatives at a global level, which will be crucial to maximize the global impact and regulatory acceptance of NGRA.
- SCCS Opinion on Biphenyl-2-ol and Sodium 2-biphenylolate used in cosmetic products (CAS/EC No. 90-43-7/201-993-5 and 132-27-4/205-055-6)– SCCS/1669/24Publication . Bernauer, Ulrike; Bodin, Laurent; Chaudhry, Qasim; Coenraads, Pieter Jan; Ezendam, Janine; Gaffet, Eric; Galli, Corrado L.; Panteri, Eirini; Rogiers, Vera; Rousselle, Christophe; Stepnik, Maciej; Vanhaecke, Tamara; Wijnhoven, Susan; Benfenati, Emilio; Corsini, Emanuela; Koutsodimou, Aglaia; Aglaia Koutsodimou; Louro, Henriqueta; Uter, Wolfgang; von Goetz, NatalieHighlights: -o-Phenylphenol (OPP) is safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off cosmetic products; - o-Phenylphenol (OPP) is safe when used as preservative up to a maximum concentration of 0.15 % in leave-on cosmetic products; - Sodium o-Phenylphenate is safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off cosmetic products; - Sodium o-Phenylphenate is safe when used as preservative up to a maximum concentration of 0.15 % in leave-on cosmetic products; - OPP and Sodium o-Phenylphenate, when used together, should not exceed the maximum concentration 0.15 % in leave-on cosmetic products; - OPP and Sodium o-Phenylphenate, when used together, should not exceed the maximum concentration 0.2 % in rinse-off cosmetic products; - Since this safety dossier related to dermally applied products only, the SCCS did not consider oral and inhalation routes; - This assessment did not cover the safety of O-Phenylphenol and Sodium o-Phenylphenate for the environment.
- Scientific Opinion on benzophenone – 4 (CAS No. 4065-45-6, EC No. 223-772-2) used in cosmetics products – SCCS/1660/23Publication . Van Haecke, Tamara; Rogiers, Vera; Scientific Committee on Consumer Safety - SCCS; Bernauer, Ulrike; Bodin, Laurent; Chaudhry, Qasim; Coenraads, Pieter Jan; Ezendam, Janine; Gaffet, Eric; Galli, Corrado L.; Panteri, Eirini; Rogiers, Vera; Rousselle, Christophe; Stepnik, Maciej; Vanhaecke, Tamara; Wijnhoven, Susan; Benfenati, Emilio; Cabaton, Nicolas; Corsini, Emanuela; Koutsodimou, Aglaia; Louro, Henriqueta; Uter, Wolfgang; von Goetz, NatalieHighlights: -BZP-4 is safe when used as UV filter up to a max. conc. of 5 % in sunscreen, all leave-on products (tot. dermal aggregate); -BZP-4 is safe when used as UV filter up to a max. conc. of 5 % in sunscreen, all rinse-off products (tot. dermal aggregate); -Same for lipstick, sunscreen propellant and pump spray (separately or in combination based on determ. aggregated exposure); -BZP-4 use as stabiliser when the product is exposed to light should remain within the conc. of. 5 %, incl. UV-filter use; -This assessment did not cover the safety of Benzophenone-4 for the environment.