Browsing by Author "Kohlenberg, Anke"
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- Emergence of ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024Publication . Kohlenberg, Anke; Svartström, Olov; Apfalter, Petra; Hartl, Rainer; Bogaerts, Pierre; Huang, Te-Din; Chudejova, Katerina; Malisova, Lucia; Eisfeld, Jessica; Sandfort, Mirco; Hammerum, Anette M.; Roer, Louise; Räisänen, Kati; Dortet, Laurent; Bonnin, Rémy A.; Tóth, Ákos; Tóth, Kinga; Clarke, Christina; Cormican, Martin; Griškevičius, Algirdas; Khonyongwa, Kirstin; Meo, Marie; Niedre-Otomere, Baiba; Vangravs, Reinis; Hendrickx, Antoni Pa; Notermans, Daan W; Samuelsen, Ørjan; Caniça, Manuela; Manageiro, Vera; Müller, Vilhelm; Mäkitalo, Barbro; Kramar, Urška; Pirs, Mateja; Palm, Daniel; Monnet, Dominique L.; Alm, Erik; Linkevicius, MariusAnalysis of 594 isolates of sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were (n = 230) and (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying have increased rapidly since 2021. The increasing detection of carbapenemase genes in the high-risk lineage ST131 is a public health concern.
- Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022Publication . Linkevicius, Marius; Bonnin, Rémy A.; Alm, Erik; Svartström, Olov; Apfalter, Petra; Hartl, Rainer; Hasman, Henrik; Roer, Louise; Räisänen, Kati; Dortet, Laurent; Pfennigwerth, Niels; Hans, Jörg B.; Tóth, Ákos; Buzgó, Lilla; Cormican, Martin; Delappe, Niall; Monaco, Monica; Giufrè, Maria; Hendrickx, Antoni P.A.; Samuelsen, Ørjan; Pöntinen, Anna K.; Caniça, Manuela; Manageiro, Vera; Oteo-Iglesias, Jesús; Pérez-Vázquez, María; Westmo, Karin; Mäkitalo, Barbro; Palm, Daniel; Monnet, Dominique L.; Kohlenberg, AnkeWhole genome sequencing data of 874 Escherichia coli isolates carrying bla NDM-5 from 13 European Union/European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ST167, ST405, ST410, ST361 and ST648, and an increasing frequency of detection. Nearly a third (30.6%) of these isolates were associated with infections and more than half (58.2%) were predicted to be multidrug-resistant. Further spread of E. coli carrying bla NDM-5 would leave limited treatment options for serious E. coli infections.
- Worsening epidemiological situation of carbapenemase-producing Enterobacteriaceae in Europe, assessment by national experts from 37 countries, July 2018Publication . Brolund, Alma; Lagerqvist, Nina; Byfors, Sara; Struelens, Marc J.; Monnet, Dominique L.; Albiger, Barbara; Kohlenberg, Anke; European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) capacity survey group, Vera)A survey on the epidemiological situation, surveillance and containment activities for carbapenemase-producing Enterobacteriaceae (CPE) was conducted in European countries in 2018. All 37 participating countries reported CPE cases. Since 2015, the epidemiological stage of CPE expansion has increased in 11 countries. Reference laboratory capability, dedicated surveillance and a specific national containment plan are in existence in 33, 27 and 14 countries, respectively. Enhanced control efforts are needed for CPE containment in Europe.