Browsing by Author "Jamal, Salima"
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- Determination of the atherogenic profile improves patient stratificatioPublication . Manaças, Ana Rita; Jamal, Salima; Alves, Ana Catarina; Rato, Quitéria; Bourbon, MafaldaIntrodution: Several charcteristics link small dense low density lipoprotein (sdLDL) subfractions to atherosclerosis, including: long residence time in plasma, enhanced oxidizability and increased permeability through the endothelial barrier. These particles contribute to an increased atherogenesis and cardiovascular (CV) risk. It is known that smaller and denser subparticles are more atherogenic than the large rand buoyant, so it’s important to quantify and know the type of sdLDL present in an individual in order to access cardiovascular risk. The main aim of this study was to analyze the atherogenic profile of subjects from a population sample.
- sdLDL-LDL ratio in familial combined hyperlipidaemia patients and familial hypercholesterolemia patientsPublication . Jamal, Salima; Alves, Ana Catarina; Medeiros, Ana Margarida; Bourbon, MafaldaIntrodution: Familial Hypercholesterolemia (FH) and Familial Combined Hypercholesterolemia (FCHL) are genetic dyslipidemias with increased cardiovascular risk. FH patients present only very high levels of LDLc since birth but FCHL patients present a complex phenotype with high LDLc and/or triglycerides that can change during the life cycle. Atherogenicity of LDL particles vary with particle size, density and lipid composition. Smaller and denser subparticles are more atherogenic than larger ones, so it’s important to quantify and know the type of sdLDL present in an individual with FH or FCHL in order to access cardiovascular risk. The aim of this study was to compare the sdLDL/LDL ratio between FH and FCHL patients with and without treatment.