Determination of the atherogenic profile improves patient stratificatio

Manaças, Ana Rita; Jamal, Salima; Alves, Ana Catarina; Rato, Quitéria; Bourbon, Mafalda

http://hdl.handle.net/10400.18/2437

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Introdution: Several charcteristics link small dense low density lipoprotein (sdLDL) subfractions to atherosclerosis, including: long residence time in plasma, enhanced oxidizability and increased permeability through the endothelial barrier. These particles contribute to an increased atherogenesis and cardiovascular (CV) risk. It is known that smaller and denser subparticles are more atherogenic than the large rand buoyant, so it’s important to quantify and know the type of sdLDL present in an individual in order to access cardiovascular risk. The main aim of this study was to analyze the atherogenic profile of subjects from a population sample.