Browsing by Author "Carvalho, S."
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- The disease modelling value of a folklore FAIRYtale: SHEDing light over a special group of genetic disordersPublication . Carvalho, S.; Santos, J.I.; Moreira, L.; Gaspar, P.; Gonçalves, M.; Encarnação, M.; Ribeiro, D.; Duarte, A.; Prata, M.J.; Coutinho, M.F.; Alves, SandraThe problem we are addressing: Despite extensive research, the links between accumulation of glycosaminoglycans (GAGs) and the clinical features seen in patients suffering from various forms of Mucopolysaccharidoses (MPSs) have yet to be further elucidated. These Lysosomal Storage Diseases (LSDs) present symptoms, which may (or may not) include critical musculoskeletal and cardiovascular alterations, respiratory problems, and serious neurological dysfunctions. The skeletal and brain systems are the hardest ones to access and, consequently, those in greatest need of additional knowledge and novel therapeutic solutions.
- The histopathological timeframe of Hyalomma lusitanicum infestation development on bovinesPublication . Zúquete, S.T.; Carvalho, S.; Santos-Silva, M.M.; Santos, A.S.; Fonseca, I.P.; Correia, J.; Cardoso, L.A.Ticks are competent vectors of both animal and human pathogens. Hard ticks secure their meals by attaching to a host for several days. Even though some animals are capable of acquiring some resistance to ticks after several infestations, tick attachment to naïve cattle often result in skin lesions because host inflammatory reaction is not enough to induce efficient responses capable of leading to ticks skins detachment. In order to characterize the recruitment of local inflammatory responses, two Holstein-Frisea females were infested with laboratory reared Hyalomma lusitanicum adult ticks.