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- Two sisters with breast cancer before age 40: two different mutations?Publication . Rodrigues, Márcia; Bastos, Fernanda; Theisen-Pereira, Patrícia; Gonçalves, JoãoIntroduction: BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) syndrome should be suspected in individuals with a personal or family history of breast cancer diagnosed at or before age 50 years.