Quaternary mixtures of TiO2NP, CeO2NP, arsenic, and mercury potentiate A549, HepG2 and SH-SY5Y cells cytotoxicity

Rosário, Fernanda; Costa, Carla; Teixeira, João; Reis, Ana Teresa

http://hdl.handle.net/10400.18/8160

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Introduction: Nanoparticles (NP) released to the environment interact with pre-existing contaminants, potentially leading to cytotoxicity and raising concerns regarding human safety to co- exposure to multiple chemicals. This work assesses and compares viability of A549, HepG2 and SH-SY5Y cells after short (24h; WST-1 assay) and long-term (7 days; clonogenic assay) exposure to single and quaternary mixtures of: titanium dioxide nanoparticles (TiO2NP) 0.75; 75 mg/L; cerium oxide nanoparticles (CeO2NP) 0.1; 10 μg/L; arsenic (As) 0.01; 0.75; 2.5 mg/L; and mercury (Hg) 0.5; 10; 20 mg/L. Mixtures were divided in four groups: low, mid-low, mid- high and high.