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Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach

2019-06-26Artigo científico Acesso restrito
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dc.contributor.authorMartins, Carla
dc.contributor.authorVidal, A.
dc.contributor.authorDe Boevre, M.
dc.contributor.authorDe Saeger, S.
dc.contributor.authorNunes, C.
dc.contributor.authorTorres, D.
dc.contributor.authorGoios, A.
dc.contributor.authorLopes, C.
dc.contributor.authorAssunção, R
dc.contributor.authorAlvito, P.
dc.date.accessioned2020-04-24T06:52:58Z
dc.date.available2020-04-24T06:52:58Z
dc.date.issued2019-06-26
dc.description.abstractMycotoxins constitute a relevant group of food contaminants with several associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring studies have been globally developed to assess the exposure to mycotoxins at individual level. In order to overcome this lack of data, the present study concerned the analysis of mycotoxins in 24h urine and first-morning urine paired samples from 94 participants enrolled within the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015–2016). Following a salt assisted matrix extraction, urine samples were analysed by liquid chromatography–mass spectrometry for the simultaneous determination of 37 urinary mycotoxins’ biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. Alternariol was identified for the first time in urine samples from a European country; however, risk characterization was not performed due to lack of reference intake value. These results confirmed mycotoxins as part of the human exposome of the Portuguese population reinforcing the need for further studies regarding the determinants of exposure.pt_PT
dc.description.sponsorshipThanks are due to FCT/MCTES for the financial support to CESAM (UID/AMB/50017/2019), through national funds. This research was also supported by the project MYTOX-SOUTH, Ghent University Global Minds programme. IAN-AF national survey was funded by the EEA Grants Program, Public Health Initiatives (PT06 - 000088SI3).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Hyg Environ Health. 2019 Jul;222(6):913-925. doi: 10.1016/j.ijheh.2019.06.010. Epub 2019 Jun 26pt_PT
dc.identifier.doidoi: 10.1016/j.ijheh.2019.06.010pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.18/6503
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Urban and Fischerpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S1438463919301518?via%3Dihubpt_PT
dc.subjectBiomarkers of Exposurept_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectMycotoxinspt_PT
dc.subjectPortugalpt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.titleExposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.endPage925pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage913pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume222pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1d7db62a-6440-4ccb-a5cc-c3f76c8585b3
relation.isProjectOfPublication.latestForDiscovery1d7db62a-6440-4ccb-a5cc-c3f76c8585b3

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