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2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children

2018-06Journal article Open access
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dc.contributor.authorKissling, Esther
dc.contributor.authorValenciano, Marta
dc.contributor.authorPozo, Francisco
dc.contributor.authorVilcu, Ana-Maria
dc.contributor.authorReuss, Annicka
dc.contributor.authorRizzo, Caterina
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorHorváth, Judit Krisztina
dc.contributor.authorBrytting, Mia
dc.contributor.authorDomegan, Lisa
dc.contributor.authorKorczyńska, Monika
dc.contributor.authorMeijer, Adam
dc.contributor.authorMachado, Ausenda
dc.contributor.authorIvanciuc, Alina
dc.contributor.authorVišekruna Vučina, Vesna
dc.contributor.authorvan der Werf, Sylvie
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorBella, Antonino
dc.contributor.authorGherasim, Alin
dc.contributor.authorFerenczi, Annamária
dc.contributor.authorZakikhany, Katherina
dc.contributor.authorO Donnell, Joan
dc.contributor.authorParadowska-Stankiewicz, Iwona
dc.contributor.authorDijkstra, Frederika
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorLazar, Mihaela
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorJohansen, Kari
dc.contributor.authorMoren, Alain
dc.contributor.authorI-MOVE/I-MOVE+ study team
dc.date.accessioned2018-02-23T17:55:22Z
dc.date.available2018-02-23T17:55:22Z
dc.date.issued2018-06
dc.descriptionI-MOVE/I-MOVE+ study team - Portugal: Verónica Gomez, Ana Paula Rodrigues, Baltazar Nunes (Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal); Pedro Pechirra, Paula Cristóvão, Patrícia Conde, Inês Costa (Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal).pt_PT
dc.description.abstractBackground:During the 2015/16 influenza season in Europe, the co-circulating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine. Methods:We used the test negative design in a multicentre case–control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients ainfluenza Vaccinend a random sample of influenza positive swabs were sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group. Results: We included 11,430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5-46.7). Among those aged 0–14, 15–64 and ≥65  years VE against A(H1N1)pdm09 was 31.9% (95% CI: -32.3-65.0), 41.4% (95%CI: 20.5-56.7) and 13.2% (95% CI: -38.0-45.3) respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95%CI: -4.1-56.7). Among those aged 0–14, 15–64 and ≥65 years VE against influenza B was -47.6% (95%CI: -124.9-3.1), 27.3% (95%CI: -4.6-49.4), and 9.3% (95%CI: -44.1-42.9) respectively. Conclusions: VE against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65  years. VE against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection are needed to understand the VE results against influenza B in the context of a mismatched vaccine.pt_PT
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in individuals aged 65 years or more. Framework contract No ECDC/2014/026pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInfluenza Other Respir Viruses. 2018 Jul;12(4):423-437. doi: 10.1111/irv.12520. Epub 2017 Nov 10pt_PT
dc.identifier.doi10.1111/irv.12520pt_PT
dc.identifier.issn1750-2640
dc.identifier.urihttp://hdl.handle.net/10400.18/5062
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/irv.12520/abstractpt_PT
dc.subjectCase Control Studypt_PT
dc.subjectInfluenzapt_PT
dc.subjectinfluenza Vaccinept_PT
dc.subjectMulticentre Studypt_PT
dc.subjectVaccine Effectivenesspt_PT
dc.subjectCuidados de Saúdept_PT
dc.subjectEfetividade da Vacina Antigripalpt_PT
dc.subjectVacina Antigripalpt_PT
dc.subjectI-MOVEpt_PT
dc.subjectI-MOVE+pt_PT
dc.title2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among childrenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/634446/EU
oaire.citation.titleInfluenza and Other Respiratory Virusespt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationccfd73a6-6f3c-4702-956c-544973bca97d
relation.isProjectOfPublication.latestForDiscoveryccfd73a6-6f3c-4702-956c-544973bca97d

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