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Human Biomonitoring: from group to personalized exposure assessment in occupational settings

2019-07-05Conference object Restricted access
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dc.contributor.authorDuca, Radu-Corneliu
dc.contributor.authorViegas, Susana
dc.contributor.authorGalea, Karen S.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSantonen, Tiina
dc.contributor.authorJones, Kate
dc.contributor.authorSepai, Ovnair
dc.date.accessioned2020-06-09T10:40:12Z
dc.date.available2020-06-09T10:40:12Z
dc.date.issued2019-07-05
dc.description.abstractThe necessity of using human biomonitoring (HBM) for chemical health risk assessment for both general population and workers has recently been brought to the fore. HBM4EU (www.hbm4eu.eu) has the main aim to coordinate and advance HBM in Europe. One of the many intended outcomes of this project is to harmonize HBM protocols and to demonstrate the utility of HBM when assessing workers exposure to chemicals. In occupational settings, analysis of environmental matrices may be insufficient to demonstrate the amount of compounds absorbed into the body. Analysis of biomarkers in biological samples to determine the internal dose is therefore an important asset in defining prevention strategies. Nevertheless, the interpretation of the HBM results might be challenging, especially at individual level, since, the absorbed dose is determined by many factors, e.g. chemical concentration, its physicochemical properties, exposure duration as well as individual factors including up-take, metabolism etc. The specificity and sensitivity of the chosen biomarker depends e.g. on its physiological half-live in the selected biological matrix. The number of compounds having recommended Biological Limit Values (BLVs) to assist in the identification of health hazards is limited. In addition, no BLVs are available for biological matrices other than urine and blood that might be related to a longer physiological half-live of the target compounds (e.g. hair) or directly related to the target organs (e.g. Exhaled Breath Condansate). However, more research is required to develop guidelines in order to choose the most appropriate biomarker and/or matrix. Within the HBM4EU occupational studies, we intend to demonstrate that the individual analysis of biomonitoring is a useful tool for personal exposure evaluation, providing information not given by inhalation and dermal exposure assessment. HBM will highlight personal working conditions and practices, taking into account individual differences and allowing more individualized measures to prevent exposure by changing individual behavior.pt_PT
dc.description.sponsorshipHBM4EU project (GA 733032)pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6971
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectHuman Biomonitoringpt_PT
dc.subjectChemical Contaminantspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHuman Biomonitoring: from group to personalized exposure assessment in occupational settingspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceBilthoven, The Netherlandspt_PT
oaire.citation.title2nd European Exposure Science Strategy Workshop (ISES Europe), 4-5 July 2019pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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