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HBM4EU Occupational Biomonitoring Study on e-Waste-Study Protocol

2021-12-09Journal article Open access
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dc.contributor.authorScheepers, Paul T.J.
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGalea, Karen S.
dc.contributor.authorGodderis, Lode
dc.contributor.authorHardy, Emilie
dc.contributor.authorKnudsen, Lisbeth E.
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMahiout, Selma
dc.contributor.authorNdaw, Sophie
dc.contributor.authorPoels, Katrien
dc.contributor.authorPorras, Simo P.
dc.contributor.authorSilva, Maria João
dc.contributor.authorTavares, Ana Maria
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorSantonen, Tiina
dc.contributor.authorHBM4EU e-Waste Study Team
dc.date.accessioned2022-01-10T16:03:10Z
dc.date.available2022-01-10T16:03:10Z
dc.date.issued2021-12-09
dc.descriptionThis article belongs to the Special Issue 2nd Edition: Human Biomonitoring of Environmental and Occupational Exposurespt_PT
dc.descriptionStudy Protocolpt_PT
dc.description.abstractWorkers involved in the processing of electronic waste (e-waste) are potentially exposed to toxic chemicals. If exposure occurs, this may result in uptake and potential adverse health effects. Thus, exposure surveillance is an important requirement for health risk management and prevention of occupational disease. Human biomonitoring by measurement of specific biomarkers in body fluids is considered as an effective method of exposure surveillance. The aim of this study is to investigate the internal exposure of workers processing e-waste using a human biomonitoring approach, which will stimulate improved work practices and contribute to raising awareness of potential hazards. This exploratory study in occupational exposures in e-waste processing is part of the European Human Biomonitoring Initiative (HBM4EU). Here we present a study protocol using a cross sectional survey design to study worker's exposures and compare these to the exposure of subjects preferably employed in the same company but with no known exposure to industrial recycling of e-waste. The present study protocol will be applied in six to eight European countries to ensure standardised data collection. The target population size is 300 exposed and 150 controls. Biomarkers of exposure for the following chemicals will be used: chromium, cadmium and lead in blood and urine; brominated flame retardants and polychlorobiphenyls in blood; mercury, organophosphate flame retardants and phthalates in urine, and chromium, cadmium, lead and mercury in hair. In addition, the following effect biomarkers will be studied: micronuclei, epigenetic, oxidative stress, inflammatory markers and telomere length in blood and metabolomics in urine. Occupational hygiene sampling methods (airborne and settled dust, silicon wristbands and handwipes) and contextual information will be collected to facilitate the interpretation of the biomarker results and discuss exposure mitigating interventions to further reduce exposures if needed. This study protocol can be adapted to future European-wide occupational studies.pt_PT
dc.description.sponsorshipThis work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Environ Res Public Health. 2021 Dec 9;18(24):12987. doi: 10.3390/ijerph182412987.pt_PT
dc.identifier.doi10.3390/ijerph182412987pt_PT
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10400.18/7842
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/24/12987pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiomarkerspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectElectronic Wastept_PT
dc.subjectOccupational Exposurept_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectCadmiumpt_PT
dc.subjectChromiumpt_PT
dc.subjectFlame Retardantspt_PT
dc.subjectLeadpt_PT
dc.subjectMercurypt_PT
dc.subjectPhthalatespt_PT
dc.subjectRecyclingpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHBM4EU Occupational Biomonitoring Study on e-Waste-Study Protocolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue24pt_PT
oaire.citation.startPage12987pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume18pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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