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Distribution of Chlamydia trachomatis ompA-genotypes over three decades in Portugal

2024-09-11Research article Restricted access
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dc.contributor.authorLodhia, Zohra
dc.contributor.authorCordeiro, Dora
dc.contributor.authorCorreia, Cristina
dc.contributor.authorJoão, Inês
dc.contributor.authorCarreira, Teresa
dc.contributor.authorVieira, Luís
dc.contributor.authorNunes, Alexandra
dc.contributor.authorFerreira, Rita
dc.contributor.authorSchäfer, Sandra
dc.contributor.authorAliyeva, Elzara
dc.contributor.authorPortugal, Clara
dc.contributor.authorMonge, Isabel
dc.contributor.authorPessanha, Maria Ana
dc.contributor.authorToscano, Cristina
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorAntunes, Marília
dc.contributor.authorGomes, Joao Paulo
dc.contributor.authorBorges, Vítor
dc.contributor.authorJosé Borrego, Maria
dc.date.accessioned2025-03-13T15:56:13Z
dc.date.available2025-03-13T15:56:13Z
dc.date.issued2024-09-11
dc.description.abstractObjectives: Chlamydia trachomatis is classified into 15 major genotypes, A to L3, based on the diversity of ompA gene. Here, we evaluated and characterised the distribution and diversity of ompA-genotypes over 32 years (1990-2021) in Portugal. Methods: The collection of the Portuguese National Reference Laboratory for Sexually Transmitted Infections includes 5824 C. trachomatis-positive samples that were successfully ompA-genotyped between 1990 and 2021. An in-depth analysis of ompA-genotypes distribution across the years, as well as by biological sex, age and anatomical site of infection was performed. Results: ompA-genotype E was consistently the most frequently detected across the years, with a median frequency of 34.6%, followed by D/Da (17.6%), F (14.3%) and G (10.7%). The prevalence of lymphogranuloma venereum (LGV) genotypes (mostly L2, 62.0%, followed by L2b, 32.1%) increased since 2016, reaching the highest value in 2019 (20.9%). LGV, G and Da genotypes were associated with biological sex, specifically with being male, and were the most frequent among anorectal specimens (37.7%, 19.4% and 17.7%, respectively). Notably, LGV ompA-genotypes represented 38.9% of the male anorectal specimens since 2016, and were also detected among oropharynx and urogenital samples. ompA-genotype E was the most frequently detected at the oropharynx (28.6%) and urogenital (33.9%) sites during the study period, followed by D/Da (17.4%) and F (16.0%) in the urogenital specimens, and by G (26.1%) and D/Da (25.7%) in oropharynx specimens. Our data also highlight the emergence of the recombinant L2b/D-Da strain since 2017 (representing between 2.0% and 15.5% of LGV cases per year) and the non-negligible detection of ompA-genotype B in urogenital and anorectal specimens. Conclusions: This study provides a comprehensive landscape of C. trachomatis molecular surveillance in Portugal, highlighting the continued relevance of ompA-genotyping as a complement to rapid LGV-specific detection tests. It also contributes to a deeper understanding of C. trachomatis epidemiology, diversity and pathogenicity.por
dc.description.sponsorshipThe work by MA is partially financed by national funds through Fundação para a Ciência e a Tecnologia under the project UIDB/00006/2020 (https://doi.org/10.54499/UIDB/00006/2020).
dc.identifier.citationSex Transm Infect. 2024 Sep 11:sextrans-2024-056166. doi: 10.1136/sextrans-2024-056166. Online ahead of print.
dc.identifier.doi10.1136/sextrans-2024-056166
dc.identifier.issn1368-4973
dc.identifier.pmid39266216
dc.identifier.urihttp://hdl.handle.net/10400.18/10439
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBMJ Publishing Group
dc.relationCentre of Statistics and its Applications
dc.relation.hasversionhttps://sti.bmj.com/content/early/2024/09/11/sextrans-2024-056166
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectChlamydia trachomatis
dc.subjectBacterial Typing Techniques
dc.subjectLymphogranuloma Venereum
dc.subjectMolecular Epidemiology
dc.subjectMolecular Typing
dc.subjectSexually Transmitted Infections
dc.subjectInfecções Sexualmente Transmissíveis
dc.subjectPortugal
dc.titleDistribution of Chlamydia trachomatis ompA-genotypes over three decades in Portugalpor
dc.typeresearch article
dcterms.referenceshttps://doi.org/10.1136/sextrans-2024-056166
dspace.entity.typePublication
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.citation.startPagesextrans-2024-056166
oaire.citation.titleSexually Transmitted Infections
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication1828b27c-0dae-4001-a56b-8e520a5b181e
relation.isProjectOfPublication.latestForDiscovery1828b27c-0dae-4001-a56b-8e520a5b181e

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