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School environment associates with lung function and autonomic nervous system activity in children: a cross-sectional study

2019-10-22Journal article Open access
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dc.contributor.authorPaciência, Inês
dc.contributor.authorRufo, João Cavaleiro
dc.contributor.authorSilva, Diana
dc.contributor.authorMartins, Carla
dc.contributor.authorMendes, Francisca
dc.contributor.authorRama, Tiago
dc.contributor.authorRodolfo, Ana
dc.contributor.authorMadureira, Joana
dc.contributor.authorDelgado, Luís
dc.contributor.authorde Oliveira Fernandes, Eduardo
dc.contributor.authorPadrão, Patrícia
dc.contributor.authorMoreira, Pedro
dc.contributor.authorSevero, Milton
dc.contributor.authorPina, Maria Fátima
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorBarros, Henrique
dc.contributor.authorRuokolainen, Lasse
dc.contributor.authorHaahtela, Tari
dc.contributor.authorMoreira, André
dc.date.accessioned2020-05-08T10:25:47Z
dc.date.available2020-05-08T10:25:47Z
dc.date.issued2019-10-22
dc.description.abstractChildren are in contact with local environments, which may affect respiratory symptoms and allergic sensitization. We aimed to assess the effect of the environment and the walkability surrounding schools on lung function, airway inflammation and autonomic nervous system activity. Data on 701 children from 20 primary schools were analysed. Lung function, airway inflammation and pH from exhaled breath condensate were measured. Pupillometry was performed to evaluate autonomic activity. Land use composition and walkability index were quantified within a 500 m buffer zone around schools. The proportion of effects explained by the school environment was measured by mixed-effect models. We found that green school areas tended to be associated with higher lung volumes (FVC, FEV1 and FEF25-75%) compared with built areas. FVC was significantly lower in-built than in green areas. After adjustment, the school environment explained 23%, 34% and 99.9% of the school effect on FVC, FEV1, and FEF25-75%, respectively. The walkability of school neighbourhoods was negatively associated with both pupil constriction amplitude and redilatation time, explaining -16% to 18% of parasympathetic and 8% to 29% of sympathetic activity. Our findings suggest that the environment surrounding schools has an effect on the lung function of its students. This effect may be partially mediated by the autonomic nervous system.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationSci Rep. 2019 Oct 22;9(1):15156. doi: 10.1038/s41598-019-51659-ypt_PT
dc.identifier.doi10.1038/s41598-019-51659-ypt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.18/6613
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-019-51659-ypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectschoolspt_PT
dc.subjectEnvironmentspt_PT
dc.subjectSchool Environmentpt_PT
dc.subjectLung Functionpt_PT
dc.subjectAirway Inflammationpt_PT
dc.subjectAutonomic Nervous Systempt_PT
dc.subjectAr e Saúde Ocupacionalpt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectAvaliação do Impacte em Saúdept_PT
dc.titleSchool environment associates with lung function and autonomic nervous system activity in children: a cross-sectional studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage15156pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume9pt_PT
rcaap.embargofctFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31641175/pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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