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Exploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022–23 VEBIS multicentre study in Europe

2024-05-03Journal article Open access
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dc.contributor.authorMaurel, Marine
dc.contributor.authorMazagatos, Clara
dc.contributor.authorGoerlitz, Luise
dc.contributor.authorOroszi, Beatrix
dc.contributor.authorHooiveld, Mariette
dc.contributor.authorMachado, Ausenda
dc.contributor.authorDomegan, Lisa
dc.contributor.authorIlić, Maja
dc.contributor.authorPopescu, Rodica
dc.contributor.authorSève, Noémie
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorBuda, Silke
dc.contributor.authorTúri, Gergő
dc.contributor.authorMeijer, Adam
dc.contributor.authorGómez, Verónica
dc.contributor.authorO'Donnell, Joan
dc.contributor.authorMlinarić, Ivan
dc.contributor.authorTimnea, Olivia
dc.contributor.authorDiez, Ana Ordax
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorHorváth, Judit Krisztina
dc.contributor.authorDijkstra, Frederika
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorMcKenna, Adele
dc.contributor.authorFilipović, Sanja Kurečić
dc.contributor.authorLazar, Mihaela
dc.contributor.authorKaczmarek, Marlena
dc.contributor.authorBacci, Sabrina
dc.contributor.authorKissling, Esther
dc.contributor.authorVEBIS study team
dc.date.accessioned2025-03-07T13:07:31Z
dc.date.available2025-03-07T13:07:31Z
dc.date.issued2024-05-03
dc.description.abstractBackground: Within influenza vaccine effectiveness (VE) studies at primary care level with a laboratory-confirmed outcome, clinical case definitions for recruitment of patients can vary. We used the 2022-23 VEBIS primary care European multicentre study end-of-season data to evaluate whether the clinical case definition affected IVE estimates. Methods: We estimated VE using a multicentre test-negative case-control design. We measured VE against any influenza and influenza (sub)types, by age group (0-14, 15-64, ≥65 years) and by influenza vaccine target group, using logistic regression. We estimated IVE among patients meeting the European Union (EU) acute respiratory infection (ARI) case definition and among those meeting the EU influenza-like illness (ILI) case definition, including only sites providing information on specific symptoms and recruiting patients using an ARI case definition (as the EU ILI case definition is a subset of the EU ARI one). Results: We included 24 319 patients meeting the EU ARI case definition, of whom 21 804 patients (90 %) meet the EU ILI case definition, for the overall pooled VE analysis against any influenza. The overall and influenza (sub)type-specific VE varied by ≤2 % between EU ILI and EU ARI populations. Discussion: Among all analyses, we found similar VE estimates between the EU ILI and EU ARI populations, with few (10%) additional non-ILI ARI patients recruited. These results indicate that VE in the 2022-23 influenza season was not affected by use of a different clinical case definition for recruitment, although we recommend investigating whether this holds true for next seasons.pt_PT
dc.description.sponsorshipECDC/2021/019/European Centre for Disease Prevention and Controlpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVaccine. 2024 Jun 11;42(16):3547-3554. doi: 10.1016/j.vaccine.2024.04.060. Epub 2024 May 3pt_PT
dc.identifier.doi10.1016/j.vaccine.2024.04.060pt_PT
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/10400.18/10421
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationECDC/2021/019pt_PT
dc.relation.ispartofVaccine
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0264410X24004973?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectClinical Case Definitionpt_PT
dc.subjectInfluenzapt_PT
dc.subjectInfluenza Vaccinept_PT
dc.subjectMulticenter Studypt_PT
dc.subjectTest-negative Designpt_PT
dc.subjectVaccine Effectivenesspt_PT
dc.subjectInfecções Respiratórias
dc.subjectCuidados de Saúde
dc.subjectEurope
dc.titleExploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022–23 VEBIS multicentre study in Europept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3554pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage3547pt_PT
oaire.citation.titleVaccinept_PT
oaire.citation.volume42pt_PT
person.familyNameMachado
person.familyNameGOMEZ TEIXEIRA PINTO
person.familyNameRodrigues
person.givenNameAusenda
person.givenNameVERÓNICA DEL PILAR
person.givenNameAna Paula
person.identifier.ciencia-id1217-6076-5D88
person.identifier.ciencia-idFA1B-D68F-2611
person.identifier.orcid0000-0002-1849-1499
person.identifier.orcid0000-0003-0485-0005
person.identifier.orcid0000-0003-2264-4723
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication544ad266-0c22-4a50-9ebc-86acc08d6666
relation.isAuthorOfPublicationeae04cda-2c73-437b-8666-6593d03aa34d
relation.isAuthorOfPublicationc23c6d96-e605-424f-abbb-64d783c73939
relation.isAuthorOfPublication.latestForDiscoveryc23c6d96-e605-424f-abbb-64d783c73939

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