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Differential Mortality Risks Associated With PM2.5 Components: A Multi-Country, Multi-City Study

2021-12-07Journal article Restricted access
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dc.contributor.authorMasselot, Pierre
dc.contributor.authorSera, Francesco
dc.contributor.authorSchneider, Rochelle
dc.contributor.authorKan, Haidong
dc.contributor.authorLavigne, Éric
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorTobias, Aurelio
dc.contributor.authorChen, Hong
dc.contributor.authorBurnett, Richard T.
dc.contributor.authorSchwartz, Joel
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorBell, Michelle L.
dc.contributor.authorChen, Bing-Yu
dc.contributor.authorGuo, Yue-Liang Leon
dc.contributor.authorRagettli, Martina S.
dc.contributor.authorVicedo-Cabrera, Ana Maria
dc.contributor.authorÅström, Christofer
dc.contributor.authorForsberg, Bertil
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorGarland, Rebecca M.
dc.contributor.authorScovronick, Noah
dc.contributor.authorMadureira, Joana
dc.contributor.authorNunes, Baltazar
dc.contributor.authorDe la Cruz Valencia, César
dc.contributor.authorHurtado Diaz, Magali
dc.contributor.authorHonda, Yasushi
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorNg, Chris Fook Cheng
dc.contributor.authorSamoli, Evangelia
dc.contributor.authorKatsouyanni, Klea
dc.contributor.authorSchneider, Alexandra
dc.contributor.authorBreitner, Susanne
dc.contributor.authorRyti, Niilo R.I.
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorMaasikmets, Marek
dc.contributor.authorOrru, Hans
dc.contributor.authorGuo, Yuming
dc.contributor.authorValdés Ortega, Nicolás
dc.contributor.authorMatus Correa, Patricia
dc.contributor.authorTong, Shilu
dc.contributor.authorGasparrini, Antonio
dc.date.accessioned2022-07-06T15:34:02Z
dc.date.available2022-07-06T15:34:02Z
dc.date.issued2021-12-07
dc.description.abstractBackground: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. Methods: We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stage, we estimated location-specific relative risks (RR) for mortality associated with daily total PM2.5 through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM2.5 components as well as meta-predictors derived from city-specific socio-economic and environmental indicators. Results: We found associations between RR and several PM2.5 components. Increasing the ammonium (NH4+) proportion from 1% to 22%, while keeping a relative average proportion of other components, increased the RR from 1.0063 (95% confidence interval [95% CI] = 1.0030, 1.0097) to 1.0102 (95% CI = 1.0070, 1.0135). Conversely, an increase in nitrate (NO3-) from 1% to 71% resulted in a reduced RR, from 1.0100 (95% CI = 1.0067, 1.0133) to 1.0037 (95% CI = 0.9998, 1.0077). Differences in composition explained a substantial part of the heterogeneity in PM2.5 risk. Conclusions: These findings contribute to the identification of more hazardous emission sources. Further work is needed to understand the health impacts of PM2.5 components and sources given the overlapping sources and correlations among many components.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEpidemiology. 2022 Mar 1;33(2):167-175. doi: 10.1097/EDE.0000000000001455. Epub 2021 Dec 7.pt_PT
dc.identifier.doi10.1097/EDE.0000000000001455pt_PT
dc.identifier.issn1044-3983
dc.identifier.urihttp://hdl.handle.net/10400.18/8071
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Healthpt_PT
dc.relation.publisherversionhttps://journals.lww.com/epidem/Abstract/2022/03000/Differential_Mortality_Risks_Associated_With_PM2_5.3.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMCCpt_PT
dc.subjectDifferential Mortality Riskspt_PT
dc.subjectPM2.5pt_PT
dc.subjectAir Pollutionpt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleDifferential Mortality Risks Associated With PM2.5 Components: A Multi-Country, Multi-City Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage175pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage167pt_PT
oaire.citation.titleEpidemiologypt_PT
oaire.citation.volume33pt_PT
person.familyNameNunes
person.givenNameBaltazar
person.identifier.ciencia-idAB11-AD48-A8DF
person.identifier.orcid0000-0001-6230-7209
person.identifier.scopus-author-id9133723200
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationbe4efa0d-49df-4a93-bfdd-b76d9f7bf492
relation.isAuthorOfPublication.latestForDiscoverybe4efa0d-49df-4a93-bfdd-b76d9f7bf492

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