Neuropsychiatric disease (NPD) clustering in families with Autism Spectrum Disorder (ASD): genetic, epigenetic and environmental issues

Marques, Ana Rita; Martiniano, Hugo; Romão, Luísa; M. Vicente, Astrid

http://hdl.handle.net/10400.18/4848

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Resumo(s)

Objectives: The aim of this project is to understand the role of epigenetic factors in ASD, with a particular focus on long noncoding lncRNA, miRNA and other regulatory molecules. For this purpose this project has two main specific objectives: 1. To identify lncRNA and miRNA loci implicated in ASD through the analysis of two large datasets with CNV and SNV data from ASD families and controls; 2. To identify genetic variants and modulating epigenetic factors that could lead to differential disease expression by exploring multiplex families in which ASD co-occurs with other NPDs.

Palavras-chave

Autism Spectrum Disorder Perturbações do Desenvolvimento Infantil e Saúde Mental

URI

http://hdl.handle.net/10400.18/4848

Editora

Instituto Nacional de Saúde Doutor Ricardo Jorge, IP

Coleções

DPSPDNT - Posters/abstracts em congressos nacionais

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