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Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18)

2019-09-17Journal article Open access
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dc.contributor.authorKissling, Esther
dc.contributor.authorPozo, Francisco
dc.contributor.authorBuda, Silke
dc.contributor.authorVilcu, Ana-Maria
dc.contributor.authorRizzo, Caterina
dc.contributor.authorGherasim, Alin
dc.contributor.authorKrisztina Horváth, Judit
dc.contributor.authorBrytting, Mia
dc.contributor.authorDomegan, Lisa
dc.contributor.authorMeijer, Adam
dc.contributor.authorParadowska-Stankiewicz, Iwona
dc.contributor.authorMachado, Ausenda
dc.contributor.authorVišekruna Vučina, Vesna
dc.contributor.authorLazar, Mihaela
dc.contributor.authorJohansen, Kari
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorvan der Werf, Sylvie
dc.contributor.authorBella, Antonino
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorFerenczi, Annamária
dc.contributor.authorZakikhany, Katherina
dc.contributor.authorO'Donnell, Joan
dc.contributor.authorDijkstra, Frederika
dc.contributor.authorBogusz, Joanna
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorPitigoi, Daniela
dc.contributor.authorPenttinen, Pasi
dc.contributor.authorValenciano, Marta
dc.contributor.authorGomez, Veronica
dc.contributor.authorKislaya, Irina
dc.contributor.authorNunes, Baltazar
dc.contributor.authorI-MOVE/I-MOVE+ study team
dc.date.accessioned2020-04-22T19:42:53Z
dc.date.available2021-12-01T01:30:13Z
dc.date.issued2019-09-17
dc.descriptionFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807025/pdf/main.pdfpt_PT
dc.description.abstractIntroduction: Influenza A(H3N2) viruses predominated in Europe in 2016–17. In 2017–18 A(H3N2) and A(H1N1)pdm09 viruses co-circulated. The A(H3N2) vaccine component was the same in both seasons; while the A(H1N1)pdm09 component changed in 2017–18. In both seasons, vaccine seed A(H3N2) viruses developed adaptations/alterations during propagation in eggs, impacting antigenicity. Methods: We used the test-negative design in a multicentre primary care case-control study in 12 European countries to measure 2016–17 and 2017–18 influenza vaccine effectiveness (VE) against laboratory-confirmed influenza A(H1N1)pdm09 and A(H3N2) overall and by age group. Results: During the 2017–18 season, the overall VE against influenza A(H1N1)pdm09 was 59% (95% CI: 47–69). Among those aged 0–14, 15–64 and ≥65 years, VE against A(H1N1)pdm09 was 64% (95% CI: 37–79), 50% (95% CI: 28–66) and 66% (95% CI: 42–80), respectively. Overall VE against influenza A(H3N2) was 28% (95% CI: 17–38) in 2016–17 and 13% (95% CI: -15 to 34) in 2017–18. Among 0–14-year-olds VE against A(H3N2) was 28% (95%CI: -10 to 53) and 29% (95% CI: -87 to 73), among 15–64-year-olds 34% (95% CI: 18–46) and 33% (95% CI: -3 to 56) and among those aged ≥65 years 15% (95% CI: -10 to 34) and -9% (95% CI: -74 to 32) in 2016–17 and 2017–18, respectively. Conclusions: Our study suggests the new A(H1N1)pdm09 vaccine component conferred good protection against circulating strains, while VE against A(H3N2) was <35% in 2016–17 and 2017–18. The egg propagation derived antigenic mismatch of the vaccine seed virus with circulating strains may have contributed to this low effectiveness. A(H3N2) seed viruses for vaccines in subsequent seasons may be subject to the same adaptations; in years with lower than expected VE, recommendations of preventive measures other than vaccination should be given in a timely manner.pt_PT
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 634446 to conduct the study in individuals aged 65 years or more. ECDC has contributed funds for the coordination and some study sites under the Framework contract no. ECDC/2014/026 for the individuals aged less than 65 years. The WHO Regional office for Europe has contributed funds for the Romanian study sitept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVaccine X. 2019 Sep 17;3:100042. doi: 10.1016/j.jvacx.2019.100042. eCollection 2019 Dec 10pt_PT
dc.identifier.doi10.1016/j.jvacx.2019.100042pt_PT
dc.identifier.issn2590-1362
dc.identifier.urihttp://hdl.handle.net/10400.18/6489
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2590136219300439?via%3Dihubpt_PT
dc.subjectCase-control Studypt_PT
dc.subjectEuropept_PT
dc.subjectInfluenzapt_PT
dc.subjectInfluenza Vaccinept_PT
dc.subjectMulticentre Studypt_PT
dc.subjectVaccine Effectivenesspt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectVacina Antigripalpt_PT
dc.subjectCuidados de Saúdept_PT
dc.subjectEfetividadept_PT
dc.subjectI-MOVEpt_PT
dc.titleEffectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016-17 and 2017-18)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/634446/EU
oaire.citation.issue17pt_PT
oaire.citation.startPage100042pt_PT
oaire.citation.titleVaccine Xpt_PT
oaire.citation.volume3pt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationccfd73a6-6f3c-4702-956c-544973bca97d
relation.isProjectOfPublication.latestForDiscoveryccfd73a6-6f3c-4702-956c-544973bca97d

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