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Overview of Adverse Outcome Pathways and Current Applications on Nanomaterials

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dc.contributor.authorRolo, Dora
dc.contributor.authorTavares, Ana
dc.contributor.authorVital, Nádia
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2022-11-29T11:33:33Z
dc.date.available2022-11-29T11:33:33Z
dc.date.issued2022
dc.description.abstractNanomaterials (NMs) have important and useful applications in chemical industry, electronics, pharmaceuticals, food and others. Their rapid proliferation presents a dilemma to regulators regarding hazard identification and increased concerns for public health. The Adverse Outcome Pathways (AOPs) are innovative central elements of a toxicological knowledge framework, developed for supporting chemical risk assessment based on mechanistic reasoning. AOPs describe a sequence of causally linked events at different levels of biological organisation, triggered by exposure to a stressor (like chemicals or NMs) leading to an adverse health effect in humans or wildlife. The integrative analysis of the cellular and molecular mechanisms of nanotoxicity towards the identification of connected adverse outcomes drives a sequential line – an AOP landscape definition. Each defined AOP is available for crossing data, linking known and unknown landscapes, reducing the reliance on animal studies, associated costs and ethical issues. NMs have unique properties, with specific associated toxicological challenges, which may represent unknown AOP landscapes. In this chapter, an overview of AOPs as important novel strategic tools in nanotoxicology is presented, highlighting the current applications in hazard identification and human health risk assessment.pt_PT
dc.description.sponsorshipThis work was funded by national funds through the FCT – Foundation for Science and Technology, I.P., under the projects PTDC/SAUPUB/29481/2017, PTDC/SAU-PUB/32587/2017 and UIDB/00009/2020; UIDP/00009/2020 (Centre for Toxicogenomics and Human Health – ToxOmics). NV is supported by the FCT PhD Scholarship 2020.07168. BD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationIn: Louro H, Silva MJ (eds). Nanotoxicology in Safety Assessment of Nanomaterials. Springer, Cham., 2022, pp. 415-39. (Advances in Experimental Medicine and Biology;1357). https://doi.org/10.1007/978-3-030-88071-2_14pt_PT
dc.identifier.doi10.1007/978-3-030-88071-2_17pt_PT
dc.identifier.eissn2214-8019
dc.identifier.issn0065-2598
dc.identifier.urihttp://hdl.handle.net/10400.18/8365
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007/978-3-030-88071-2_17pt_PT
dc.subjectNanomaterialspt_PT
dc.subjectAdverse Outcome Pathwayspt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleOverview of Adverse Outcome Pathways and Current Applications on Nanomaterialspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.endPage439pt_PT
oaire.citation.startPage415pt_PT
oaire.citation.titleAdvances in Experimental Medicine and Biologypt_PT
oaire.citation.volume(Advances in Experimental Medicine and Biology;1357)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameLouro
person.givenNameMaria João
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0001-8821-0747
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
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