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Ciguatera toxins, a potential health risk emerging in Europe: overview of progress and challenges

2025-03-19Journal article Restricted access
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datacite.subject.fosCiências Naturais
datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorAlvito, Paula
dc.contributor.authorGago-Martínez, Ana
dc.contributor.editorAlvito
dc.date.accessioned2026-01-09T12:16:23Z
dc.date.available2026-01-09T12:16:23Z
dc.date.issued2025-03-19
dc.description.abstractCiguatera Poisoning (CP) is considered an emerging risk of concern in several places worldwide. The risk of CP in Europe is currently being investigated, and important advantages have been achieved under two EuroCigua projects, which allowed the characterization of Caribbean Ciguatoxins as the main responsible for the contamination in the European Coastal areas investigated. Important challenges and limitations, particularly the ones related to the lack of reference materials and of relevant samples that enable to associate the contaminated fish consumption with human intoxication, are the most critical aspects hindering the progress from both analytical and toxicological perspectives. This review aims to provide an update on the most recent advances in CP in Europe on the source of the toxins involved in contamination, their toxicology and pharmacology, and their detection and characterization in order to contribute to envisioning the toxic mechanism of CP in humans.eng
dc.description.abstractHighlights: - C-CTXs have been confirmed as responsible for CP in Europe. - N2a-MTT and Mass Spectrometry allowed the characterization of C-CTXs. - The lack of Reference Materials limits CTX characterization. - Semipurified reference materials for C-CTXs were developed under EuroCigua projects. - C-CTXs were not found in Gambierdiscus sp. from the areas of study.por
dc.description.sponsorshipA. Gago-Martinez acknowledges the financial support of the European Food Safety Authority (EFSA), Italy, under the EuroCigua projects (FPA GP/EFSA/AFSCO/2015/03 and GP/EFSA/KNOW/2022/03); P. Alvito acknowledges UID Centro de Estudos do Ambiente e do Mar (CESAM), Portugal (LA/P/0094/2020).
dc.identifier.citationCurr Opin Food Sci. 2025 Jun;63:101303. doi: 10.1016/j.cofs.2025.101303. Epub 2025 Mar 19
dc.identifier.doi10.1016/j.cofs.2025.101303
dc.identifier.eissn2214-8000
dc.identifier.issn2214-7993
dc.identifier.urihttp://hdl.handle.net/10400.18/10671
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre for Environmental and Marine Studies
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2214799325000335
dc.relation.ispartofseriesSpecial Issue; Food Toxicology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCiguatera Poisoning
dc.subjectMarine Biotoxins
dc.subjectSeafood Poisoning
dc.subjectToxinas Marinhas
dc.subjectEurope
dc.subjectSegurança Alimentar
dc.subjectToxicologia
dc.titleCiguatera toxins, a potential health risk emerging in Europe: overview of progress and challengeseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PT
oaire.citation.startPage101303
oaire.citation.titleCurrent Opinion in Food Science
oaire.citation.volume63
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublicationbc5e46b5-0da4-4ee2-97e0-bf2ab95a5870
relation.isProjectOfPublication.latestForDiscoverybc5e46b5-0da4-4ee2-97e0-bf2ab95a5870

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