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Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives

2023-03Journal article Open access
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dc.contributor.authorPerestrelo, Sara
dc.contributor.authorAmaro, Ana
dc.contributor.authorBrouwer, Michael S.M.
dc.contributor.authorClemente, Lurdes
dc.contributor.authorRibeiro Duarte, Ana Sofia
dc.contributor.authorKaesbohrer, Annemarie
dc.contributor.authorKarpíšková, Renata
dc.contributor.authorLopez-Chavarrias, Vicente
dc.contributor.authorMorris, Dearbháile
dc.contributor.authorPrendergast, Deirdre
dc.contributor.authorPista, Angela
dc.contributor.authorSilveira, Leonor
dc.contributor.authorSkarżyńska, Magdalena
dc.contributor.authorSlowey, Rosemarie
dc.contributor.authorVeldman, Kees T.
dc.contributor.authorZając, Magdalena
dc.contributor.authorBurgess, Catherine
dc.contributor.authorAlvarez, Julio
dc.date.accessioned2024-01-24T16:23:26Z
dc.date.available2024-01-24T16:23:26Z
dc.date.issued2023-03
dc.description(This article belongs to the Special Issue Epidemiology of ESBL-Producing Enterobacteriaceae)pt_PT
dc.description.abstractAntimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.pt_PT
dc.description.sponsorshipThis research was funded by Promoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance, and emerging microbiological hazards–One Health EJP, grant number 773830 (DiSCoVeR). Research at the German Federal Institute for Risk Assessment, Germany, was partially supported by the internal project BfR-BIOS-08-43-001. Research at the National Institute for Agrarian and Veterinary Research (INIAV) was partially supported by the project PTDC/CVT-CVT/28469/2017 financed by the “Fundação para a Ciência e Tecnologia” (FCT), Portugal. Research at the National Veterinary Research Institute (PIWet), Poland, was also partially supported by the Polish Ministry of Education and Science from the funds for science in the years 2018–2022 allocated for the implementation of a co-financed international project. The environmental isolates from Ireland were collected as part of the AREST project, which is jointly funded by the Environmental Protection Agency, under the EPA Research Programme 2014–2020, and the Health Service Executive (2017-HW-LS-1). The isolates collected from pig farms in Ireland were collected as part of a Walsh Scholarship project funded by Teagasc (ref 2018027). Research at the VISAVET Health Surveillance Centre (Spain) was partially supported by the project Antimicrobial resistance transmission dynamics in the human-animal interface: Shaping the risk posed by epidemic plasmids (PID2021-125136OB-I00, Ministerio de Ciencia, Innovación y Universidades, MICINN).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntibiotics (Basel). 2023 Mar 10;12(3):552. doi: 10.3390/antibiotics12030552.pt_PT
dc.identifier.doi10.3390/antibiotics12030552pt_PT
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10400.18/8972
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
dc.relationFood-producing animals as reservoirs of resistance to Critically Important Antibiotics
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/12/3/552pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAmpC beta-lactamase (AmpC)pt_PT
dc.subjectEscherichia colipt_PT
dc.subjectExtended-spectrum Beta-lactamase (ESBLpt_PT
dc.subjectMonitoringpt_PT
dc.subjectOne Healthpt_PT
dc.subjectGastrointestinal Infectionspt_PT
dc.subjectFoodborne Zoonosespt_PT
dc.subjectAntimicrobial Resistancept_PT
dc.subjectInfecções Gastrointestinaispt_PT
dc.titleBuilding an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
oaire.awardTitleFood-producing animals as reservoirs of resistance to Critically Important Antibiotics
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/773830/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT-CVT%2F28469%2F2017/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage552pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamH2020
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication94d118fb-33ce-49fa-b1ed-d5bddf63581d
relation.isProjectOfPublication274ed6bf-8e05-48f4-b02a-1aa7078cea43
relation.isProjectOfPublication.latestForDiscovery274ed6bf-8e05-48f4-b02a-1aa7078cea43

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