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Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age

2024-03-19Journal article Open access
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dc.contributor.authorQueiroz, Guilherme
dc.contributor.authorMonteiro, Celdidy
dc.contributor.authorManco, Licínio
dc.contributor.authorRelvas, Luís
dc.contributor.authorTrovoada, Maria de Jesus
dc.contributor.authorLeite, Andreia
dc.contributor.authorBento, Celeste
dc.date.accessioned2025-01-29T16:30:59Z
dc.date.available2025-01-29T16:30:59Z
dc.date.issued2024-03-19
dc.description.abstractBackground Sickle Cell Disorder is Africa’s most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors. Methods: We conducted a cluster survey in 35 neighbourhoods. Haemoglobin was assessed through point-of-care capillary electrophoresis or high-performance liquid chromatography, and sociodemographic data through questionnaires. The weighted prevalence of sickle cell trait (HbAS) and HbC carriers was estimated with a 95% confidence interval (95% CI). We calculated weighted prevalence ratios (95% CI) through robust Poisson regression for its association with age and individual and collective genetic heritage. Findings: The prevalence of sickle cell trait in women of reproductive age in São Tomé e Príncipe (n = 376) was 13.45% (95% CI: 9.05-19.00). The prevalence of HbC carriers was 8.00% (95% CI: 4.71-12.00). Older age and speaking Forro or Angolar were positively associated with having sickle cell trait. Interpretation: The prevalence of sickle cell trait in São Tomé e Príncipe ranks high in the West African region. The country should follow international guidelines, implementing newborn screening and comprehensive healthcare management.pt_PT
dc.description.sponsorshipCIAS-UC (FCT: UIDB/00283/2020), APPDH and Forum Haematologico. This work was funded by CIAS - supported by FCT - Foundation for Science and Technology, I.P., within the scope of the project UIDB/00283/2020CIAS-UC - who paid for the ARKRAY® Lab001 and reagents for all the laboratory work, the flight and travel expenses of CB, the flight to Príncipe of GQ and publishing fees. APPDH paid for the flights of GQ to São Tomé. Forum Hematologico de Coimbra paid for the impression of forms and informed consent.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Public Health. 2024 Mar 19;24(1):850. doi: 10.1186/s12889-024-17761-1
dc.identifier.doi10.1186/s12889-024-17761-1pt_PT
dc.identifier.issn1471-2458
dc.identifier.pmid38504224
dc.identifier.urihttp://hdl.handle.net/10400.18/10320
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relation.hasversionhttps://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-17761-1
dc.relation.publisherversionhttps://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-17761-1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCluster Sampling
dc.subjectGenetics
dc.subjectHaemoglobinopathies
dc.subjectSickle Cell Disease
dc.subjectSub-saharian Africa
dc.subjectAnemia Células Falciformespt_PT
dc.subjectSão Tomé e Príncipept_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleSickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive agept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage850
oaire.citation.titleBMC Public Healthpt_PT
oaire.citation.volume24pt_PT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLeite
person.givenNameAndreia
person.identifier1052436
person.identifier.ciencia-id2F10-F9A9-E8A7
person.identifier.orcid0000-0003-0843-0630
person.identifier.scopus-author-id57109931300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication838ff85b-16c9-4992-b13f-e3099f916717
relation.isAuthorOfPublication.latestForDiscovery838ff85b-16c9-4992-b13f-e3099f916717

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