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Helicobacter pylori infection: from standard to alternative treatment strategies

2022-05Journal article Restricted access
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dc.contributor.authorSousa, Cláudia
dc.contributor.authorFerreira, Rute
dc.contributor.authorAzevedo, Nuno F.
dc.contributor.authorOleastro, Mónica
dc.contributor.authorAzeredo, Joana
dc.contributor.authorFigueiredo, Ceu
dc.contributor.authorMelo, Luís D.R.
dc.date.accessioned2023-02-27T14:27:53Z
dc.date.available2023-02-27T14:27:53Z
dc.date.issued2022-05
dc.description.abstractHelicobacter pylori is the major component of the gastric microbiome of infected individuals and one of the aetiological factors of chronic gastritis, peptic ulcer disease and gastric cancer. The increasing resistance to antibiotics worldwide has made the treatment of H. pylori infection a challenge. As a way to overhaul the efficacy of currently used H. pylori antibiotic-based eradication therapies, alternative treatment strategies are being devised. These include probiotics and prebiotics as adjuvants in H. pylori treatment, antimicrobial peptides as alternatives to antibiotics, photodynamic therapy ingestible devices, microparticles and nanoparticles applied as drug delivery systems, vaccines, natural products, and phage therapy. This review provides an updated synopsis of these emerging H. pylori control strategies and discusses the advantages, hurdles, and challenges associated with their development and implementation. An effective human vaccine would be a major achievement although, until now, projects regarding vaccine development have failed or were discontinued. Numerous natural products have demonstrated anti-H. pylori activity, mostly in vitro, but further clinical studies are needed to fully disclose their role in H. pylori eradication. Finally, phage therapy has the potential to emerge as a valid alternative, but major challenges remain, namely the isolation of more H. pylori strictly virulent bacterio(phages).pt_PT
dc.description.sponsorshipThis work was supported by the Portuguese Foundation for Science and Technology – Fundaçao para a Ciência e Tecnologia (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit, and Project PTDC/SAU-PUB/29182/2017 [POCI-01-0145-FEDER-029182]. RF is recipient of a FCT PhD grant with the reference SFRH/BD/146496/2019.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCrit Rev Microbiol. 2022 May;48(3):376-396. doi: 10.1080/1040841X.2021.1975643. Epub 2021 Sep 27pt_PT
dc.identifier.doi10.1080/1040841X.2021.1975643pt_PT
dc.identifier.issn1040-841X
dc.identifier.urihttp://hdl.handle.net/10400.18/8526
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor and Francispt_PT
dc.relationCentre of Biological Engineering of the University of Minho
dc.relationA new strategy to combat Helicobacter pylori infections based on chimeric phages
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/1040841X.2021.1975643pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHeliocbacter pyloript_PT
dc.subjectAlternative Treatmentspt_PT
dc.subjectAntibiotic Resistancept_PT
dc.subjectInfecções Gastrointestinaispt_PT
dc.titleHelicobacter pylori infection: from standard to alternative treatment strategiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Biological Engineering of the University of Minho
oaire.awardTitleA new strategy to combat Helicobacter pylori infections based on chimeric phages
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-PUB%2F29182%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F146496%2F2019/PT
oaire.citation.endPage396pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage376pt_PT
oaire.citation.titleCritical Reviews in Microbiologypt_PT
oaire.citation.volume48pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamPOR_NORTE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication7943bed3-8247-4296-abf0-957ef0a00120
relation.isProjectOfPublication4118b900-7c6f-4ebb-9ffb-f7f7b5db8b8a
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relation.isProjectOfPublication.latestForDiscovery7943bed3-8247-4296-abf0-957ef0a00120

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