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Portuguese children dietary exposure to multiple mycotoxins – An overview of risk assessment under MYCOMIX project

2018-08Journal article Restricted access
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dc.contributor.authorAssunção, Ricardo
dc.contributor.authorMartins, Carla
dc.contributor.authorVasco, Elsa
dc.contributor.authorJager, Alessandra
dc.contributor.authorOliveira, Carlos
dc.contributor.authorCunha, Sara
dc.contributor.authorFernandes, José O
dc.contributor.authorNunes, Baltazar
dc.contributor.authorLoureiro, Susana
dc.contributor.authorAlvito, Paula
dc.date.accessioned2019-02-12T12:37:57Z
dc.date.available2019-02-12T12:37:57Z
dc.date.issued2018-08
dc.description.abstractMycotoxins are secondary fungi metabolites that induce acute and chronic toxic effects in humans and animals. Simultaneous contamination of cereal-based products by multiple mycotoxins has been increasingly reported, including in food products usually consumed by children. Although some previous authors assessed the health risk of children exposed to multiple mycotoxins, scarce data are available on the risk associated with the ingestion of multiple mycotoxins through different food products. MYCOMIX, a national funded project, intended to contribute to fill this gap. The present study aimed to overview the risk assessment of multiple mycotoxins performed under MYCOMIX, assessing for the first time, the risk associated with the exposure to 13 mycotoxins in breakfast cereals, infant cereals and biscuits consumed by children from Lisbon region, Portugal. Results on mycotoxins occurrence showed that 94% of samples were contaminated with at least one mycotoxin, although at levels below the legislated limits. Co-contamination was observed in 75% of the analysed samples. Estimated aflatoxins exposure suggested a potential adverse health effect for percentiles of intake above or equal to P50. The obtained results suggested that future research actions should be set in motion in order to protect children health.pt_PT
dc.description.sponsorshipThis research was performed under the MYCOMIX project “Exploring the toxic effects of mixtures of mycotoxins in infant food and potential health impact” (PTDC/DTP-FTO/0417/2012), and CESAM funded by the Portuguese Foundation for Science and Technology (FCT) (UID/AMB/50017/2013), through national funds, and the co-funding by the FEDER (POCI-01-0145-FEDER-00763), within the PT2020 Partnership Agreement and Compete 2020. Sara Cunha and José Fernandes thanks REQUIMTE FCT and FEDER through the project UID/QUI/50006/2013 - POCI/01/0145/FEDER/007265 with financial support from FCT/MEC through national funds and co-financed by FEDER, under the Partnership Agreement PT2020. Ricardo Assunção also thanks to “BioMAN | Incentivo de Estudos de Biomonitorização Humana de Âmbito Nacional” (BioMAN/DAN/01). Sara C. Cunha acknowledges FCT for IF/01616/2015 contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFood Chem Toxicol. 2018 Aug;118:399-408. doi: 10.1016/j.fct.2018.05.040. Epub 2018 May 21pt_PT
dc.identifier.doi10.1016/j.fct.2018.05.040pt_PT
dc.identifier.issn0278-691
dc.identifier.urihttp://hdl.handle.net/10400.18/5756
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Pergamonpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0278691518303405?via%3Dihubpt_PT
dc.subjectCumulative Risk Assessmentpt_PT
dc.subjectChildrenpt_PT
dc.subjectMultiple Mycotoxinspt_PT
dc.subjectCereal-based Foodspt_PT
dc.subjectMYCOMIX Projectpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectPortugalpt_PT
dc.subjectDeterminantes da Saúde e da Doença
dc.titlePortuguese children dietary exposure to multiple mycotoxins – An overview of risk assessment under MYCOMIX projectpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0417%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage408pt_PT
oaire.citation.startPage399pt_PT
oaire.citation.titleFood and Chemical Toxicologypt_PT
oaire.citation.volume118pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPolítica editorial da revista.
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication7dee8a4a-7112-45ce-a8cb-8c552d7ae061
relation.isProjectOfPublication1d7db62a-6440-4ccb-a5cc-c3f76c8585b3
relation.isProjectOfPublicationd7883dc7-6335-4f26-8bd0-e2ea4bb07c07
relation.isProjectOfPublication.latestForDiscovery7dee8a4a-7112-45ce-a8cb-8c552d7ae061

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