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Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal

2018-12-07Journal article Open access
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dc.contributor.authorIgrejas, Gilberto
dc.contributor.authorCorreia, Susana
dc.contributor.authorSilva, Vanessa
dc.contributor.authorHébraud, Michel
dc.contributor.authorCaniça, Manuela
dc.contributor.authorTorres, Carmen
dc.contributor.authorGomes, Catarina
dc.contributor.authorNogueira, Fernanda
dc.contributor.authorPoeta, Patrícia
dc.date.accessioned2019-03-26T16:01:58Z
dc.date.available2019-03-26T16:01:58Z
dc.date.issued2018-12-07
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292916/pt_PT
dc.description.abstractMethicillin-resistant Staphylococcus aureus (MRSA) is one of the most important multidrug-resistant nosocomial pathogens worldwide with infections leading to high rates of morbidity and mortality, a significant burden to human and veterinary clinical practices. The ability of S. aureus colonies to form biofilms on biotic and abiotic surfaces contributes further to its high antimicrobial resistance (AMR) rates and persistence in both host and non-host environments, adding a major ecological dimension to the problem. While there is a lot of information on MRSA prevalence in humans, data about MRSA in animal populations is scarce, incomplete and dispersed. This project is an attempt to evaluate the current epidemiological status of MRSA in Portugal by making a single case study from a One Health perspective. We aim to determine the prevalence of MRSA in anthropogenic sources liable to contaminate different animal habitats. The results obtained will be compiled with existing data on antibiotic resistant staphylococci from Portugal in a user-friendly database, to generate a geographically detailed epidemiological output for surveillance of AMR in MRSA. To achieve this, we will first characterize AMR and genetic lineages of MRSA circulating in northern Portugal in hospital wastewaters, farms near hospitals, farm animals that contact with humans, and wild animals. This will indicate the extent of the AMR problem in the context of local and regional human-animal-environment interactions. MRSA strains will then be tested for their ability to form biofilms. The proteomes of the strains will be compared to better elucidate their AMR mechanisms. Proteomics data will be integrated with the genomic and transcriptomic data obtained. The vast amount of information expected from this omics approach will improve our understanding of AMR in MRSA biofilms, and help us identify new vaccine candidates and biomarkers for early diagnosis and innovative therapeutic strategies to tackle MRSA biofilm-associated infections and potentially other AMR superbugs.pt_PT
dc.description.sponsorshipThis article is based upon work from COST Action (‘Network for Evaluation of One Health’, NEOH, TD14040), supported by COST (European Cooperation in Science and Technology). The authors are grateful to the Associate Laboratory Research Unit for Green Chemistry (LAQV), which is financed by National Funds from FCT/MEC (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 partnership agreement (POCI-01-0145- FEDER – 007265).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Microbiol. 2018 Dec 7;9:2964. doi: 10.3389/fmicb.2018.02964. eCollection 2018.pt_PT
dc.identifier.doi10.3389/fmicb.2018.02964pt_PT
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/10400.18/6312
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmicb.2018.02964/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMethicillin-resistant Staphylococcus aureuspt_PT
dc.subjectMRSApt_PT
dc.subjectOne Healthpt_PT
dc.subjectAntimicrobial Resistancept_PT
dc.subjectOmicspt_PT
dc.subjectSurveillancept_PT
dc.subjectResistência aos Antimicrobianospt_PT
dc.titlePlanning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.startPage2964pt_PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPolítica editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationd7883dc7-6335-4f26-8bd0-e2ea4bb07c07
relation.isProjectOfPublication.latestForDiscoveryd7883dc7-6335-4f26-8bd0-e2ea4bb07c07

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