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Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola

2022-03-27Journal article Open access
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dc.contributor.authorFançony, Cláudia
dc.contributor.authorSoares, Ânia
dc.contributor.authorLavinha, João
dc.contributor.authorBrito, Miguel
dc.date.accessioned2023-01-09T14:59:39Z
dc.date.available2023-01-09T14:59:39Z
dc.date.issued2022-03-27
dc.descriptionThis article belongs to the Section Micronutrients and Human Health.pt_PT
dc.description.abstractIn host organisms with normal micronutrient status, nutritional immunity is a strongly regulated response aiming at decreasing the progression and severity of infections. Zinc deficiency may disturb this balance, impairing immune responses to infections, which may indirectly increase infection-related anemia. Since zinc deficiency may associate directly with anemia, the role of infections is often overlooked. Herein, we investigated the participation of infections (or inflammation) in the causal pathway between zinc deficiency and anemia. This transversal study, conducted in 2015 in Bengo-Angola, enrolled 852 under-3-year-old children. Logistic regression models were used to investigate interaction and mediation effects, and significance was confirmed by the Sobel test. In sum, 6.8% of children had zinc deficiency, 45.9% had anemia, and 15.6% had at least one intestinal/urogenital parasite. Furthermore, we found (1) no evidence that inflammation mediates or interacts with zinc deficiency to cause anemia, and (2) zinc deficiency interacts with infections, significantly increasing the odds of anemia (OR: 13.26, p = 0.022). This interaction was stronger among children with iron deficiency anemia (OR: 46.66, p = 0.003). Our results suggest that zinc deficiency may impair the immune response to infections and/or that intestinal parasites could have developed mechanisms to avoid zinc-limited environments. Further studies are needed to corroborate these suggestions.pt_PT
dc.description.sponsorshipThis study had financial support from the Fundação Calouste Gulbenkian and Camões IP, Instituto da Cooperação e da Língua from Portugalpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients. 2022 Mar 27;14(7):1392. doi: 10.3390/nu14071392.pt_PT
dc.identifier.doidoi.org/10.3390/nu14071392pt_PT
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.18/8408
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=nu14071392pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnemiapt_PT
dc.subjectInfectionspt_PT
dc.subjectInflammationpt_PT
dc.subjectZinc Deficiencypt_PT
dc.subjectAngolapt_PT
dc.subjectDoenças Genéticaspt_PT
dc.subjectZincopt_PT
dc.subjectInfeçãopt_PT
dc.subjectInflamaçãopt_PT
dc.titleZinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angolapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1392pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume14pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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