Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface

Marques, L.; Auriac, A.; Willemetz, A.; Banha, J.; Silva, B.; Canonne-Hergaux, F.; Costa, L.

http://hdl.handle.net/10400.18/1106

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Resumo(s)

Ceruloplasmin is a positive acute-phase protein with both anti- and pro-oxidant activities, thus having still unclear physiological functions in inflammatory processes. Importantly, ceruloplasmin has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin on cellular iron efflux. Ceruloplasmin can be expressed as a secreted or as a membrane glycosylphosphatidylinositol-anchored protein (GPI-ceruloplasmin), this latter one being reported as expressed mostly in the brain.

Palavras-chave

GPI-ceruloplasmin Ferroportin Lipid Raft Immune Cells Hepatocytes Iron Metabolism Determinantes Imunológicos em Doenças Crónicas

URI

http://hdl.handle.net/10400.18/1106

Citação

Blood Cells Mol Dis. 2012 Feb 15;48(2):110-20. Epub 2011 Dec 16.

Editora

Elsevier

Coleções

DPSPDNT - Artigos em revistas internacionais

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