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Systematic review on toxicological effects of platinum nanoparticles: towards their use as safe biomedical tools

2025-11-06Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Medicina Básica
dc.contributor.authorTouzani, Assia
dc.contributor.authorRamos-Pan, Lucía
dc.contributor.authorFraga, Sónia
dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.date.accessioned2026-02-03T15:49:52Z
dc.date.available2026-02-03T15:49:52Z
dc.date.issued2025-11-06
dc.description.abstractPlatinum nanoparticles (PtNP) have received considerable attention in the nanomedicine field due to their magnetic, catalytic, and optical properties. However, the potential toxicity of PtNP has not been properly evaluated yet, and current information on the possible risks related to their use is still limited. On this basis, the main objective of this systematic review was to gather available data on PtNP biological behaviour and potential harmful effects, as well as to highlight the gaps of knowledge that need to be filled in to progress in their use in clinical practice. A total of 441 studies were obtained and reviewed from the initial search; 108 fulfilled the selection criteria and were included in the revision. Mainly in vitro but also in vivo studies were reported using a variety of biological systems and animal models, with no data from human epidemiological studies published so far. All these studies were extensively evaluated to provide useful information on the PtNP biocompatibility and their potential to be employed for medical purposes. In particular, information on the physicochemical features of the PtNP influencing their biological behaviour, methods employed for toxicity evaluation, biological systems used, and outcomes addressed were analysed and discussed. In general, the results obtained showed a good biocompatibility of these NP, although some of them detected significant toxicity highly dependent of size, concentration/dose, coating, or exposed biological system. Furthermore, anticancer or protective effects were also described for PtNP in several revised studies. These findings encourage to continue exploring the benefits of PtNP for clinical practice.eng
dc.description.abstractHighlights: -Platinum nanoparticles (PtNP) are promising tools in the biomedicine field. -Lack of information on biocompatibility or potential toxicity is limiting their use. -This systematic review compiles data on PtNP biological behaviour and toxic effects. -108 studies were included and knowledge gaps for clinical progress were identified. -Results showed a good biocompatibility of PtNP with no or limited harmful effects.eng
dc.description.sponsorshipThis research was funded by Ministry of Science and Innovation: MCIN/AEI/10.13039/501100011033 (Grant PID2020–114908GA-I00),Xunta de Galicia (ED431B2022/16) and Foundation for Science and Technology – FCT (Portuguese Ministry of Science, Technology and Higher Education) under the projects POCI-01–0145-FEDER-031898, UIDB/04750/2020 and LA/P/0064/2020, with DOI identifiers https://doi.org/10.54499/UIDB/04750/2020 and https://doi.org/10.54499/LA/P/0064/2020. L. R.-P. was supported by a Ministry of Science and Innovation predoctoral fellowship (grant number FPU2023/03379). Funding for open access charge: Universidade da Coruña/CISUG.
dc.identifier.citationMutat Res Rev Mutat Res. 2025 Jul-Dec:796:108554. doi: 10.1016/j.mrrev.2025.108554. Epub 2025 Nov 6
dc.identifier.doi10.1016/j.mrrev.2025.108554
dc.identifier.eissn1388-2139
dc.identifier.issn1383-5742
dc.identifier.pmid41205441
dc.identifier.urihttp://hdl.handle.net/10400.18/10800
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relationPOCI-01–0145-FEDER-031898
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S1383574225000250
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPlatinum Nanoparticles
dc.subjectSystematic Review
dc.subjectCytotoxicity
dc.subjectGenotoxicity
dc.subjectEmbryotoxicity
dc.subjectBiocompatibility
dc.subjectGenotoxicidade Ambiental
dc.titleSystematic review on toxicological effects of platinum nanoparticles: towards their use as safe biomedical toolseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.startPage108554
oaire.citation.titleMutation Research - Reviews in Mutation Research
oaire.citation.volume796
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

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