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Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites

2016-07-15Journal article Restricted access
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dc.contributor.authorOliveira, Marta
dc.contributor.authorSlezakova, Klara
dc.contributor.authorAlves, Maria José
dc.contributor.authorFernandes, Adília
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorPereira, Maria do Carmo
dc.contributor.authorMorais, Simone
dc.date.accessioned2016-10-28T15:38:09Z
dc.date.available2020-07-16T00:30:11Z
dc.date.issued2016-07-15
dc.description.abstractThe concentrations of six urinary monohydroxyl metabolites (OH-PAHs) of polycyclic aromatic hydrocarbons, namely 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene (1OHPy), and 3-hydroxybenzo[a]pyrene, were assessed in the post-shift urine of wildland firefighters involved in fire combat activities at six Portuguese fire corporations, and compared with those of non-exposed subjects. Overall, median levels of urinary individual and total OH-PAHs (ΣOH-PAHs) suggest an increased exposure to polycyclic aromatic hydrocarbons during firefighting activities with ΣOH-PAH levels in exposed firefighters 1.7-35 times higher than in non-exposed ones. Urinary 1-hydroxynaphthalene and/or 1-hydroxyacenapthene were the predominant compounds, representing 63-98% of ΣOH-PAHs, followed by 2-hydroxyfluorene (1-17%), 1-hydroxyphenanthrene (1-13%), and 1OHPy (0.3-10%). A similar profile was observed when gender discrimination was considered. Participation in fire combat activities promoted an increase of the distribution percentage of 1-hydroxynaphthalene and 1-hydroxyacenaphthene, while contributions of 1-hydroxyphenanthrene and 1OHPy decreased. The detected urinary 1OHPy concentrations (1.73×10(-2) to 0.152μmol/mol creatinine in exposed subjects versus 1.21×10(-2) to 5.44×10(-2)μmol/mol creatinine in non-exposed individuals) were lower than the benchmark level (0.5μmol/mol creatinine) proposed by the American Conference of Governmental Industrial Hygienists. This compound, considered the biomarker of exposure to PAHs, was the less abundant one from the six analyzed biomarkers. Thus the inclusion of other metabolites, in addition to 1OHPy, in future studies is suggested to better estimate firefighters' occupational exposure to PAHs. Moreover, strong to moderate Spearman correlations were observed between individual compounds and ΣOH-PAHs corroborating the prevalence of an emission source.pt_PT
dc.description.sponsorshipThis study was financed by European (FEDER funds through COMPETE) and National (Fundação para a Ciência e Tecnologia project UID/QUI/50006/2013) funds and in the scope of the P2020 Partnership Agreement Project POCI-01-0145-FEDER-006939 (Laboratory for Process Engineering, Environment, Biotechnology and Energy—LEPABE) funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI). Authors are also grateful to for the financial support through the fellowships (SFRH/BD/80113/2011 and SFRH/BPD/65722/2009).pt_PT
dc.identifier.citationInt J Hyg Environ Health. 2016 Nov;219(8):857-866. doi: 10.1016/j.ijheh.2016.07.011. Epub 2016 Jul 15.pt_PT
dc.identifier.doi10.1016/j.ijheh.2016.07.011pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.18/4071
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/Urban and Fischerpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1438463916301547pt_PT
dc.subjectWildland Firefighterspt_PT
dc.subjectPolycyclic Aromatic Hydrocarbonspt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectBiomarkers of Exposurept_PT
dc.subjectUrinary Monohydroxyl Metabolitespt_PT
dc.subjectAr e Saúde Ocupacionalpt_PT
dc.titleFirefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolitespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPolítica de copyright e de auto-arquivo do editor.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationd7883dc7-6335-4f26-8bd0-e2ea4bb07c07
relation.isProjectOfPublication.latestForDiscoveryd7883dc7-6335-4f26-8bd0-e2ea4bb07c07

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