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Epidemiological Data and Antimicrobial Resistance of Campylobacter spp. in Portugal from 13 Years of Surveillance

2024-02-06Research article Open access
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dc.contributor.authorDuarte, Andreia
dc.contributor.authorPereira, Luísa
dc.contributor.authorLemos, Maria-Leonor
dc.contributor.authorPinto, Miguel
dc.contributor.authorRodrigues, João Carlos
dc.contributor.authorMatias, Rui
dc.contributor.authorSantos, Andrea
dc.contributor.authorPTCampyNet
dc.contributor.authorOleastro, Mónica
dc.date.accessioned2025-03-20T14:36:29Z
dc.date.available2025-03-20T14:36:29Z
dc.date.issued2024-02-06
dc.description(This article belongs to the Special Issue Epidemiology and Molecular Pathogenesis of Antimicrobial Resistance and Virulence for Foodborne Pathogens)
dc.description.abstractThis study extensively analyzed campylobacteriosis surveillance in Portugal from 2009 to 2021, aiming to investigate demographic shifts, seasonal variations, and antimicrobial resistance (AMR) within Campylobacter isolates. Surveillance network and sentinel laboratory-based system data revealed a substantial under-notification of campylobacteriosis cases, suggesting an underestimated disease burden. Notification rates exhibited a paradigm shift, with a notable prevalence among the pediatric population, particularly in children aged 1-4 years, diverging from European reports. Additionally, an emerging trend of Campylobacter infections in younger adults (15-44 years) was observed. The study unveiled a unique seasonal distribution of cases, defying typical summer peaks seen elsewhere. AMR analysis revealed high resistance to ciprofloxacin and tetracycline, in both C. jejuni (93.7% and 79.2%, respectively) and C. coli (96.5% and 93.2%, respectively), stable throughout the studied period (2013-2021). C. coli exhibited significantly higher resistance to erythromycin, gentamicin, ampicillin and ertapenem compared to C. jejuni (p < 0.001). Multilocus Sequence Typing (MLST) data demonstrated the distribution of resistance markers across diverse sequence types, challenging the notion of a clonal origin for multidrug-resistant isolates. In conclusion, the study highlights the need for enhanced surveillance and raises concerns about alarming AMR levels, recommending the implementation of whole-genome sequencing (WGS)-based surveillance for a deeper comprehension of disease patterns and an evolving AMR landscape. eng
dc.description.sponsorshipThis work was partly supported by funding from the European Union’s Horizon 2020 Research and Innovation program under grant agreement No 773830: One Health European Joint Program. Maria-Leonor Lemos is the recipient of a PhD grant (2022.10133.BD) from Fundação para a Ciência e a Tecnologia (FCT).
dc.identifier.citationPathogens. 2024 Feb 6;13(2):147. doi: 10.3390/pathogens13020147
dc.identifier.doi10.3390/pathogens13020147
dc.identifier.eissn2076-0817
dc.identifier.pmid38392885
dc.identifier.urihttp://hdl.handle.net/10400.18/10449
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationPromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
dc.relationEvaluating dogs as host of highly pathogenic Campylobacter jejuni: from genomics to functional assessment through a One Health approach
dc.relation.hasversionhttps://www.mdpi.com/2076-0817/13/2/147
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCampylobacter Infection
dc.subjectEpidemiology
dc.subjectSurveillance
dc.subjectNotification
dc.subjectAntibiotic Resistance
dc.subjectWhole-genome Sequencing
dc.subjectResistance Genetic Determinants
dc.subjectInfecções Gastrointestinais
dc.titleEpidemiological Data and Antimicrobial Resistance of Campylobacter spp. in Portugal from 13 Years of Surveillancepor
dc.typeresearch article
dspace.entity.typePublication
oaire.awardTitlePromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
oaire.awardTitleEvaluating dogs as host of highly pathogenic Campylobacter jejuni: from genomics to functional assessment through a One Health approach
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/773830/EU
oaire.awardURIhttp://hdl.handle.net/10400.18/10448
oaire.citation.issue2
oaire.citation.startPage147
oaire.citation.titlePathogens
oaire.citation.volume13
oaire.fundingStreamH2020
oaire.fundingStreamOE
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
relation.isProjectOfPublication94d118fb-33ce-49fa-b1ed-d5bddf63581d
relation.isProjectOfPublication13ed8d41-ccf9-4fc6-8875-e84fafcd062a
relation.isProjectOfPublication.latestForDiscovery94d118fb-33ce-49fa-b1ed-d5bddf63581d

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