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Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma

2021-07-28Artigo científico Acesso aberto
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dc.contributor.authorBorges, Vítor
dc.contributor.authorIsidro, Joana
dc.contributor.authorCunha, Mário
dc.contributor.authorCochicho, Daniela
dc.contributor.authorMartins, Luís
dc.contributor.authorBanha, Luís
dc.contributor.authorFigueiredo, Margarida
dc.contributor.authorRebelo, Leonor
dc.contributor.authorTrindade, Maria Céu
dc.contributor.authorDuarte, Sílvia
dc.contributor.authorVieira, Luís
dc.contributor.authorAlves, Maria João
dc.contributor.authorCosta, Inês
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorSantos, Madalena
dc.contributor.authorCortê-Real, Rita
dc.contributor.authorDias, André
dc.contributor.authorPóvoas, Diana
dc.contributor.authorCabo, João
dc.contributor.authorFigueiredo, Carlos
dc.contributor.authorManata, Maria José
dc.contributor.authorMaltez, Fernando
dc.contributor.authorGomes da Silva, Maria
dc.contributor.authorGomes, João Paulo
dc.date.accessioned2022-07-03T16:11:04Z
dc.date.available2022-07-03T16:11:04Z
dc.date.issued2021-07-28
dc.description.abstractRecent studies have shown that persistent SARS-CoV-2 infections in immunocompromised patients can trigger the accumulation of an unusual high number of mutations with potential relevance at both biological and epidemiological levels. Here, we report a case of an immunocompromised patient (non-Hodgkin lymphoma patient under immunosuppressive therapy) with a persistent SARS-CoV-2 infection (marked by intermittent positivity) over at least 6 months. Viral genome sequencing was performed at days 1, 164, and 171 to evaluate SARS-CoV-2 evolution. Among the 15 single-nucleotide polymorphisms (SNPs) (11 leading to amino acid alterations) and 3 deletions accumulated during this long-term infection, four amino acid changes (V3G, S50L, N87S, and A222V) and two deletions (18-30del and 141-144del) occurred in the virus Spike protein. Although no convalescent plasma therapy was administered, some of the detected mutations have been independently reported in other chronically infected individuals, which supports a scenario of convergent adaptive evolution. This study shows that it is of the utmost relevance to monitor the SARS-CoV-2 evolution in immunocompromised individuals, not only to identify novel potentially adaptive mutations, but also to mitigate the risk of introducing "hyper-evolved" variants in the community.pt_PT
dc.description.abstractIMPORTANCE Tracking the within-patient evolution of SARS-CoV-2 is key to understanding how this pandemic virus shapes its genome toward immune evasion and survival. In the present study, by monitoring a long-term COVID-19 immunocompromised patient, we observed the concurrent emergence of mutations potentially associated with immune evasion and/or enhanced transmission, mostly targeting the SARS-CoV-2 key host-interacting protein and antigen. These findings show that the frequent oscillation in the immune status in immunocompromised individuals can trigger an accelerated virus evolution, thus consolidating this study model as an accelerated pathway to better understand SARS-CoV-2 adaptive traits and anticipate the emergence of variants of concern.pt_PT
dc.description.sponsorshipThis study was partially cofunded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Program (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationmSphere. 2021 Aug 25;6(4):e0024421. doi: 10.1128/mSphere.00244-21. Epub 2021 Jul 28.pt_PT
dc.identifier.doi10.1128/mSphere.00244-21pt_PT
dc.identifier.issn2379-5042
dc.identifier.urihttp://hdl.handle.net/10400.18/8052
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Microbiologypt_PT
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/mSphere.00244-21pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectConvergent Evolutionpt_PT
dc.subjectGenome Sequencingpt_PT
dc.subjectImmunocompromised Hostpt_PT
dc.subjectLong-term Infectionpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleLong-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPagee0024421pt_PT
oaire.citation.titlemSpherept_PT
oaire.citation.volume6pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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