Repository logo
 
Publication

Replication of the CELSR1 association with ischemic stroke in a Portuguese case-control cohort

2011-07Journal article Open access
Simple item page
dc.contributor.authorGouveia, Liliana O.
dc.contributor.authorSobral, João
dc.contributor.authorVicente, A.M.
dc.contributor.authorFerro, José M.
dc.contributor.authorOliveira, Sofia A.
dc.date.accessioned2011-09-07T14:05:22Z
dc.date.available2011-09-07T14:05:22Z
dc.date.issued2011-07
dc.description.abstractOBJECTIVES: Replication of GWAS association findings remains the gold standard for results validation. Our aim was to test the association of four polymorphisms (rs1671021 in LLGL2, rs753307 in RUVBL2, rs6007897 and rs4044210 in CELSR1) previously identified as ischemic stroke (IS) risk factors in a phased GWAS performed on 6341 Japanese individuals [1]. METHODS: These polymorphisms were genotyped in a Portuguese sample of 566 IS cases and 525 controls, and their allele, genotype and haplotype associations were assessed. RESULTS: rs6007897 and rs4044210 in CELSR1 were associated with stroke risk individually (OR[95%CI]=1.43[1.13-1.81], p=0.003 and 1.38[1.09-1.74], p=0.007, respectively), and in combination as a haplotype. These associations remain after correction for multiple testing and in a meta-analysis with the original findings. The other polymorphisms were not associated. CONCLUSIONS: Our study independently confirmed for the first time the association between IS and CELSR1. This finding and the mechanisms by which these genetic variants exert their effects on stroke pathogenesis warrant further replication and investigationpor
dc.identifier.citationAtherosclerosis. 2011 Jul;217(1):260-2. Epub 2011 Mar 29por
dc.identifier.issn0021-9150
dc.identifier.urihttp://hdl.handle.net/10400.18/124
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0021915011002838por
dc.subjectCELSR1por
dc.subjectAssociationpor
dc.subjectIschemic strokepor
dc.subjectGWASpor
dc.subjectDoenças Cardio e Cérebro-vascularespor
dc.titleReplication of the CELSR1 association with ischemic stroke in a Portuguese case-control cohortpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage262por
oaire.citation.startPage260por
oaire.citation.titleAtherosclerosispor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Replication ofthe CELSR1 association withischemicstrokeinaPortuguese.pdf
Size:
118.49 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DPSPDNT - Artigos em revistas internacionais