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Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement

2020-10-11Journal article Open access
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dc.contributor.authorJenks, Jeffrey D.
dc.contributor.authorGangneux, Jean-Pierre
dc.contributor.authorSchwartz, Ilan S.
dc.contributor.authorAlastruey-Izquierdo, Ana
dc.contributor.authorLagrou, Katrien
dc.contributor.authorThompson III, George R.
dc.contributor.authorLass-Flörl, Cornelia
dc.contributor.authorHoenigl, Martin
dc.contributor.authorEuropean Confederation of Medical Mycology (ECMM) Council Investigators
dc.date.accessioned2021-03-09T17:34:25Z
dc.date.available2021-03-09T17:34:25Z
dc.date.issued2020-10-11
dc.descriptionECMM Council Investigators: Z. Adamski, S. Arikan-Akdagli, V. Arsic-Arsenijevic, O.A. Cornely, N. Friberg, N. Gow, S. Hadina, P. Hamal, M. Juerna-Ellam, N. Klimko, L. Klingspor, F. Lamoth, M. Mares, T. Matos, V. Ozenci, T. Papp, E. Roilides, R. Sabino, E. Segal, A.F. Talento, A.M. Tortorano, P. Verweij.pt_PT
dc.descriptionR. Sabino, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugalpt_PT
dc.descriptionCommunicationpt_PT
dc.description.abstractBreakthrough invasive fungal infections (bIFI) cause significant morbidity and mortality. Their diagnosis can be challenging due to reduced sensitivity to conventional culture techniques, serologic tests, and PCR-based assays in patients undergoing antifungal therapy, and their diagnosis can be delayed contributing to poor patient outcomes. In this review, we provide consensus recommendations on behalf of the European Confederation for Medical Mycology (ECMM) for the diagnosis of bIFI caused by invasive yeasts, molds, and endemic mycoses, to guide diagnostic efforts in patients receiving antifungals and support the design of future clinical trials in the field of clinical mycology. The cornerstone of lab-based diagnosis of breakthrough infections for yeast and endemic mycoses remain conventional culture, to accurately identify the causative pathogen and allow for antifungal susceptibility testing. The impact of non-culture-based methods are not well-studied for the definite diagnosis of breakthrough invasive yeast infections. Non-culture-based methods have an important role for the diagnosis of breakthrough invasive mold infections, in particular invasive aspergillosis, and a combination of testing involving conventional culture, antigen-based assays, and PCR-based assays should be considered. Multiple diagnostic modalities, including histopathology, culture, antibody, and/or antigen tests and occasionally PCR-based assays may be required to diagnose breakthrough endemic mycoses. A need exists for diagnostic tests that are effective, simple, cheap, and rapid to enable the diagnosis of bIFI in patients taking antifungals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Fungi (Basel). 2020 Oct 11;6(4):216. doi: 10.3390/jof6040216.pt_PT
dc.identifier.doi10.3390/jof6040216pt_PT
dc.identifier.issn2309-608X
dc.identifier.urihttp://hdl.handle.net/10400.18/7379
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2309-608X/6/4/216pt_PT
dc.subjectBreakthrough Invasive Fungal Infectionspt_PT
dc.subjectInvasive Candidiasispt_PT
dc.subjectInvasive Mold Infectionspt_PT
dc.subjectEndemic Mycosespt_PT
dc.subjectdiagnosticspt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleDiagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statementpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage216pt_PT
oaire.citation.titleJournal of Fungipt_PT
oaire.citation.volume6pt_PT
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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