Logo do repositório
 
Publicação

Evaluation of Bile Salts on the Survival and Modulation of Virulence of Aliarcobacter butzleri

2023-08-30Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorMateus, Cristiana
dc.contributor.authorMaia, Cláudio J.
dc.contributor.authorDomingues, Fernanda
dc.contributor.authorBücker, Roland
dc.contributor.authorOleastro, Mónica
dc.contributor.authorFerreira, Susana
dc.date.accessioned2024-02-12T15:40:41Z
dc.date.available2024-02-12T15:40:41Z
dc.date.issued2023-08-30
dc.description(This article belongs to the Special Issue Arcobacteraceae and Campylobacteraceae: Prevalence, Virulence and Antibiotics Resistance)pt_PT
dc.description.abstractAliarcobacter butzleri is a Gram-negative bacterium associated with infections of the gastrointestinal tract and widely distributed in various environments. For successful infection, A. butzleri should be able to tolerate various stresses during gastrointestinal passage, such as bile. Bile represents an antimicrobial host barrier that acts against external noxious agents and consists of a variety of bile salts. The intestinal bile salts act as detergents involved in the antimicrobial host defense; although, on the bacterial side, they could also serve as a signal to activate virulence mechanisms. The aim of this work was to understand the effects of bile salts on the survival and virulence of A. butzleri. In our study, A. butzleri was able to survive in the presence of human physiological concentrations of bile salts. Regarding the virulence features, an increase in cellular hydrophobicity, a decrease in motility and expression of flaA gene, as well as an increase in biofilm formation with a concomitant change in the type of biofilm structure were observed in the presence of sub-inhibitory concentration of bile salts. Concerning adhesion and invasion ability, no significant difference was observed. Overall, the results demonstrated that A. butzleri is able to survive in physiological concentrations of bile salts and that exposure to bile salts could change its virulence mechanisms.pt_PT
dc.description.sponsorshipFunding: This research was developed within the scope of the CICS-UBI projects UIDB/00709/2020 and UIDP/00709/2020, funded by national funds through the Portuguese Foundation for Science and Technology/MCTES. Cristiana Mateus is recipient of a doctoral fellowship (UI/BD/151023/2021) under the scope of the CICS-UBI Programmatic Funding (UIDP/00709/2020). Susana Ferreira acknowledges UBI and FCT by the contract of Scientific Employment according to DL57/2016. The microscopy facility used in the development of this work is part of the PPBI-Portuguese Platform of BioImaging and is partially supported by the Project POCI-01-0145-FEDER-022122.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntibiotics (Basel). 2023 Aug 30;12(9):1387. doi: 10.3390/antibiotics12091387pt_PT
dc.identifier.doi10.3390/antibiotics12091387pt_PT
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10400.18/9088
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationUnravelling the virulence potential of Aliarcobacter butzleri
dc.relationNot Available
dc.relationPortuguese Platform of BioImaging
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/12/9/1387pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAliarcobacter butzleript_PT
dc.subjectVirulencept_PT
dc.subjectBile Saltspt_PT
dc.subjectGastrointestinal Infectionspt_PT
dc.subjectInfecções Gastrointestinaispt_PT
dc.titleEvaluation of Bile Salts on the Survival and Modulation of Virulence of Aliarcobacter butzleript_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleUnravelling the virulence potential of Aliarcobacter butzleri
oaire.awardTitleNot Available
oaire.awardTitlePortuguese Platform of BioImaging
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151023%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL57%2F2016%2FCP1334%2FCP1644%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9444 - RNIIIE/PINFRA%2F22122%2F2016/PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1387pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamDL 57/2016
oaire.fundingStream9444 - RNIIIE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationced21566-cfde-4640-afff-0536a07c1f8f
relation.isProjectOfPublicatione0fbaa7c-391a-479d-9bcf-efb7997d4004
relation.isProjectOfPublication60f6a70b-110d-4c15-a3fd-d43d078078bc
relation.isProjectOfPublicationcd8d582a-84fb-439a-a2c7-aa4ec69e78b4
relation.isProjectOfPublication5bab81a0-d349-4efa-84cb-117ccaf04333
relation.isProjectOfPublication.latestForDiscoveryced21566-cfde-4640-afff-0536a07c1f8f

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Biles salts, Arcobacter_2023.pdf
Tamanho:
20.54 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

DDI - Artigos em revistas internacionais