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Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Survey

2023-06-30Journal article Embargoed access
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dc.contributor.authorMarques, José Gonçalo
dc.contributor.authorInácio Cunha, Florbela Maria
dc.contributor.authorBajanca-Lavado, Maria Paula
dc.contributor.authorPortuguese Study Group on Haemophilus influenzae Invasive Disease in Children
dc.date.accessioned2023-10-09T14:27:59Z
dc.date.embargo2026-07-01
dc.date.issued2023-06-30
dc.descriptionPortuguese Study Group on Haemophilus influenzae Invasive Disease in Children: Celia Bettencourt, Arminda Maria Jorge, Maria Conceição Faria, Carla Zilhão, Laura Marques, Conceição Casanova, Cristiana Pereira, Fernando Fonseca, Cláudia Monteiro, Mariana Bettencourt, Diana Moreira, Fernanda Rodrigues, Henrique Oliveira, Catarina Sousa, Graciete Pinheiro, Sara Diogo Santos, Adília Vicente, Tiago Milheiro, Margarida Pinto, Graça Seves, Rosa Bento, M ª João Virtuoso, Rita Fonseca, Maria Dinah Carvalho, Luís Lito, Carla Cruz, Adriana Coutinho, Paula Correia, Luísa Sancho, Elzara Aliyeva, Cristina Freitas, Nuno Canhoto, Ana Filipa Nunes, Ana Maria Queiroz, José Diogo, Maria Manuel Flores, Paula Reis, Elmano Ramalheira, Maria Manuel Zarcos, Sofia Lima, Susana Castilho, Catarina Lacerda, Luísa Teixeira, Ana Maria Jesus, Sofia Maia Aroso, Margarida Tavares, Bonito Vitor, Angélica Ramos, Manuela Costa Alves, Isabel Cunha, Alberta Faustino, Álvaro Sousa, Margarida Rodrigues, Idalina Maciel, Sandra Vieira, Jorge Rodrigues, Elisabete Santos, Alexandra Costa, Filomena Martins, Carlos Escobar, Pedro Flores, Maria Favila Menezes, João Calado Nunes, Ana Neto, Marina Soares, Rita Mouro Pinto, Diana Almeida, Isabel Brito, Hermínia Costa, Fátima Silva, Joana Cardoso, Magalys Pereira, Luís Gonçalves, João Tavares, Sofia Botelho Moniz, Eurico Jorge Gaspar, Joana Carvalho, Ana Paula Castro, Álvaro Sousa, Catarina Francisco, João Farela Neves, Paulo Paixão.pt_PT
dc.description.abstractBackground: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic and molecular studies were performed at the same Reference Laboratory. Clinical data were collected by the referring pediatrician. Results: Hib was identified in 41 children with ID and 26 (63%) were considered VF. Nineteen (73%) cases occurred in children less than 5 years old; 12 (46%) occurred before the Hib vaccine booster dose at 18 months of age. Comparing the first and the last 6-year periods of the study, the incidence rate of Hib, VF and total H. influenzae (Hi) ID significantly raised ( P < 0.05). VF cases corresponded, respectively, to 13.5% (7/52) and 22% (19/88) of total Hi-ID cases ( P = 0.232). Two children died due to epiglottitis and 1 acquired sensorineural hearing loss. Only 1 child had an inborn error of immunity. The immunologic workup performed in 9 children revealed no significant abnormalities. All 25 Hib-VF strains analyzed belonged to the same clonal complex 6. Conclusions: In Portugal, more than 95% of children are vaccinated against Hib, but severe Hib-ID cases still occur. No predisposing factors were clearly identified to justify the increased number of VF in recent years. Along with continued Hi-ID surveillance, Hib colonization and serologic studies should be implemented.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPediatr Infect Dis J. 2023 Sep 1;42(9):824-828. doi: 10.1097/INF.0000000000004011. Epub 2023 Jun 30pt_PT
dc.identifier.doi10.1097/INF.0000000000004011pt_PT
dc.identifier.issn0891-3668
dc.identifier.urihttp://hdl.handle.net/10400.18/8675
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Health, Inc.pt_PT
dc.relation.publisherversionhttps://journals.lww.com/pidj/fulltext/2023/09000/haemophilus_influenzae_type_b_vaccine_failure_in.21.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHaemophilus influenzaept_PT
dc.subjectVaccine Failurept_PT
dc.subjectHIB Vaccinept_PT
dc.subjectChildrenpt_PT
dc.subjectInvasive Diseasept_PT
dc.subjectPortugalpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.subjectDoenças Evitáveis pela Vacinaçãopt_PT
dc.titleHaemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multicenter Pediatric Surveypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage828pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage824pt_PT
oaire.citation.titleThe Pediatric Infectious Disease Journalpt_PT
oaire.citation.volume42pt_PT
rcaap.embargofctAcesso de acordo com a página web da revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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