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RSV-Bacterial Co-Infection Is Associated With Increased Illness Severity in Hospitalized Children - Results From a Prospective Sentinel Surveillance Study

2025-02-08Journal article Restricted access
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dc.contributor.authorTorres, Ana Rita
dc.contributor.authorGaio, Vânia
dc.contributor.authorMelo, Aryse
dc.contributor.authorLança, Miguel
dc.contributor.authorBarreto, Marta
dc.contributor.authorLagoa Gomes, Licínia Isabel
dc.contributor.authorAzevedo, Inês
dc.contributor.authorBandeira, Teresa
dc.contributor.authorLito, David
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorVigiRSV group
dc.date.accessioned2025-07-01T14:49:24Z
dc.date.available2025-07-01T14:49:24Z
dc.date.issued2025-02-08
dc.description.abstractDuring the autumn/winter respiratory syncytial virus (RSV) epidemics, bacterial co-infection is common and affects the disease severity. We aimed to understand the relationship between RSV-bacterial co-infections and clinical severity since the RSV seasonality change after COVID-19 pandemic. We conducted a prospective, sentinel surveillance study at 20 sites in Portugal in children under 2 years hospitalized with RSV, between April 21 and January 23. Effect of co-infection with potentially pathogenic bacteria (PPB) on the length of hospitalization and disease severity was investigated using multivariate linear and log-binomial regression models. Among 678 RSV hospitalizations, 67.4% occurred in children under 6 months and 15.3% in preterm; 20.4% tested positive for PPB; median length of hospitalization was 5 days (IQR: 3-7days). Children coinfected with PPB had a higher rate of ICU admission (29.7% vs. 3.5%, p < 0.001), resulting in more prolonged hospitalizations (7 vs. 5 days, p < 0.001) and a 13-fold risk of having severe disease (RR: 13.2, 95% CI:7.3-23.9). RSV-bacterial co-infection was associated with increased length of hospitalization and severe illness during off-season epidemics. This risk is probably overestimated, as laboratory testing for bacterial infections is usually higher in severely ill-appearing children. Measures to prevent outgrowth of pathogenic bacteria within the respiratory tract should be discussed.eng
dc.identifier.citationJ Med Virol. 2025 Feb;97(2):e70209. doi: 10.1002/jmv.70209
dc.identifier.doi10.1002/jmv.70209
dc.identifier.issn0146-6615
dc.identifier.pmid39921395
dc.identifier.urihttp://hdl.handle.net/10400.18/10523
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/jmv.70209
dc.rights.uriN/A
dc.subjectRSV
dc.subjectAcute Respiratory Infection
dc.subjectChildren
dc.subjectCo‐infections
dc.subjectEstados de Saúde e de Doença
dc.subjectInfecções Respiratórias
dc.titleRSV-Bacterial Co-Infection Is Associated With Increased Illness Severity in Hospitalized Children - Results From a Prospective Sentinel Surveillance Studyeng
dc.typejournal article
dcterms.referenceshttps://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fjmv.70209&file=jmv70209-sup-0001-Supplementary_Material_20240916.docx
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.startPagee70209
oaire.citation.titleJournal of Medical Virology
oaire.citation.volume97
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGaio
person.familyNameBarreto
person.familyNameLagoa Gomes
person.familyNameGuiomar
person.familyNameRodrigues
person.givenNameVânia
person.givenNameMarta
person.givenNameLicínia Isabel
person.givenNameRaquel
person.givenNameAna Paula
person.identifier.ciencia-idA71A-17AF-30C7
person.identifier.ciencia-id3613-9A7C-524A
person.identifier.ciencia-idF71A-B53C-3BE1
person.identifier.ciencia-idAE10-5FAB-7439
person.identifier.orcid0000-0001-7626-4991
person.identifier.orcid0000-0001-6464-548X
person.identifier.orcid0009-0009-0214-9646
person.identifier.orcid0000-0002-4563-6315
person.identifier.orcid0000-0003-2264-4723
person.identifier.ridF-5591-2012
person.identifier.scopus-author-id56080468200
person.identifier.scopus-author-id7004455392
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relation.isAuthorOfPublication.latestForDiscovery59791814-187c-4b34-b3a2-6ad67a213814

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