Electron-microscopy characterization of cells infected with a new phlebovirus isolated in sandflies from south Portugal

Amaro, Fátima; Zé-Zé, Líbia; Alves, M.J.; Alves de Matos, A.P.

http://hdl.handle.net/10400.18/3408

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Abstract(s)

Phlebovirus genus is comprised by arthropod-borne viruses and is one of the five genera that compose Bunyaviridae family [1]. Viruses within this family mature intracellularly and their RNA replicates in the cytoplasm, while the viral proteins transit through the Endoplasmic Reticulum and Golgi apparatus [2]. Serological studies in human Portuguese populations have proven that Toscana virus, a neurotropic phlebovirus, is present in Portugal but there were no data about phleboviral activity in arthropod vectors [3]. In this context, and in order to detect sandflies naturally infected by phleboviruses, an entomological surveillance was conducted in Arrabida region, in the south of Portugal.