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Influenza vaccine effectiveness in Europe and the birth cohort effect against influenza A(H1N1)pdm09: VEBIS primary care multicentre study, 2023/24

2025-06-12Texto Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg17:Parcerias para a Implementação dos Objetivos
dc.contributor.authorKissling, Esther
dc.contributor.authorMaurel, Marine
dc.contributor.authorPozo, Francisco
dc.contributor.authorPérez-Gimeno, Gloria
dc.contributor.authorBuda, Silke
dc.contributor.authorSève, Noémie
dc.contributor.authorDomegan, Lisa
dc.contributor.authorHooiveld, Mariëtte
dc.contributor.authorOroszi, Beatrix
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorLatorre-Margalef, Neus
dc.contributor.authorMlinarić, Ivan
dc.contributor.authorLazar, Mihaela
dc.contributor.authorGiménez Duran, Jaume
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorEnouf, Vincent
dc.contributor.authorMcKenna, Adele
dc.contributor.authorde Lange, Marit
dc.contributor.authorTúri, Gergő
dc.contributor.authorTrobajo-Sanmartín, Camino
dc.contributor.authorGOMEZ TEIXEIRA PINTO, VERÓNICA DEL PILAR
dc.contributor.authorSamuelsson Hagey, Tove
dc.contributor.authorVišekruna Vučina, Vesna
dc.contributor.authorCherciu, Maria Carmen
dc.contributor.authorGarcía Vazquez, Miriam
dc.contributor.authorErdwiens, Annika
dc.contributor.authorMasse, Shirley
dc.contributor.authorBennett, Charlene
dc.contributor.authorMeijer, Adam
dc.contributor.authorKristóf, Katalin
dc.contributor.authorCastilla, Jesús
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorIvanciuc, Alina Elena
dc.contributor.authorBacci, Sabrina
dc.contributor.authorKaczmarek, Marlena
dc.date.accessioned2026-01-27T16:03:24Z
dc.date.available2026-01-27T16:03:24Z
dc.date.issued2025-06-12
dc.descriptionVebis team: Nuno Verdasca, Licínia Gomes, Camila Henriques, Daniela Dias, (Infectious Diseases Department, Instituto Nacional deSaúde Doutor Ricardo Jorge), João Santos, Ausenda Machado (Epidemiology Department, Instituto Nacional de Saúde.
dc.description.abstractIntroduction: Influenza A(H1N1)pdm09, A(H3N2) and B/Victoria viruses circulated in Europe in 2023/24, with A(H1N1)pdm09 dominance. First influenza infections in childhood may lead to different vaccine effectiveness (VE) in subsequent years. Aim: The VEBIS primary care network estimated influenza VE in Europe using a multicentre test-negative study. Methods: Primary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We estimated VE against influenza (sub)type and clade, by age group and by year of age for A(H1N1)pdm09, using logistic regression. Results: We included 29,958 patients, with 3,054, 1,053 and 311 influenza A(H1N1)pdm09, A(H3N2) and B cases, respectively. All-age VE against influenza A(H1N1)pdm09 was 52% (95% CI: 44-59). By year of age, VE was 27% (95% CI: -2 to 47) at 44 years with peaks at 72% (95% CI: 52-84) and 54% (95% CI: 41-64) among children and those 65 years and older, respectively. All-age A(H1N1)pdm09 VE against clade 5a.2a was 41% (95% CI: 24-54) and -11% (95% CI: -69 to 26) against clade 5a.2a.1. The A(H3N2) VE was 35% (95% CI: 20-48) among all ages and ranged between 34% and 40% by age group. All-age VE against clade 2a.3a.1 was 38% (95% CI: 1-62). All-age VE against B/Victoria was 83% (95% CI: 65-94), ranging between 70 and 92% by age group. Discussion: The 2023/24 VEBIS primary care VE against medically attended symptomatic influenza infection was high against influenza B/Victoria, but lower against influenza A(H1N1)pdm09 and A(H3N2). Clade- and age-specific effects may have played a role in the lower A(H1N1)pdm09 VE.eng
dc.description.sponsorshipThe ‘Vaccine Effectiveness, Burden and Impact Studies’ (VEBIS) is a project of the European Centre for Disease Prevention and Control (ECDC) run under the framework con- tract No. ECDC/2021/019. For Germany, this work has received additional financial support from the German Federal Ministry of Health (IMS-RKI and IMS-NRZ/KL projects) on the basis of a resolution of the German Bundestag.
dc.identifier.citationEuro Surveill. 2025 Jun;30(23):2500011. doi: 10.2807/1560-7917.ES.2025.30.23.2500011
dc.identifier.doi10.2807/1560-7917.ES.2025.30.23.2500011
dc.identifier.eissn1025-496X
dc.identifier.issn40511473
dc.identifier.pmid40511473
dc.identifier.urihttp://hdl.handle.net/10400.18/10768
dc.language.isoeng
dc.peerreviewedyes
dc.publisherEuropean Centre for Disease Prevention and Control
dc.relation.hasversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.23.2500011
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectInfluenza
dc.subjectCase-Control Study
dc.subjectInfluenza Vaccines
dc.subjectImprinting
dc.subjectMulticentre Study
dc.subjectVaccine Effectiveness
dc.subjectVEBIS
dc.subjectEstados de Saúde e de Doença
dc.subjectInvestigação em Serviços de Saúde
dc.titleInfluenza vaccine effectiveness in Europe and the birth cohort effect against influenza A(H1N1)pdm09: VEBIS primary care multicentre study, 2023/24por
dc.typetext
dspace.entity.typePublication
oaire.citation.issue23
oaire.citation.startPage2500011
oaire.citation.titleEurosurveillance: Europe's journal on infectious disease surveillance, epidemiology, prevention and control
oaire.citation.volume30
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGuiomar
person.familyNameGOMEZ TEIXEIRA PINTO
person.familyNameRodrigues
person.givenNameRaquel
person.givenNameVERÓNICA DEL PILAR
person.givenNameAna Paula
person.identifier.ciencia-idAE10-5FAB-7439
person.identifier.ciencia-idFA1B-D68F-2611
person.identifier.orcid0000-0002-4563-6315
person.identifier.orcid0000-0003-0485-0005
person.identifier.orcid0000-0003-2264-4723
relation.isAuthorOfPublication9743082d-bed6-4e5e-94f5-1d27bb037bb0
relation.isAuthorOfPublicationeae04cda-2c73-437b-8666-6593d03aa34d
relation.isAuthorOfPublicationc23c6d96-e605-424f-abbb-64d783c73939
relation.isAuthorOfPublication.latestForDiscoveryeae04cda-2c73-437b-8666-6593d03aa34d

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