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Diversity of Human T-Lymphotropic Virus Type 1 Cosmopolitan Subtype (HTLV-1a) Circulating in Infected Residents in Portugal

2023-08-11Journal article Restricted access
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dc.contributor.authorQuina, Miriam
dc.contributor.authorRamos, Diogo
dc.contributor.authorSilva, Carolina
dc.contributor.authorPádua, Elizabeth
dc.date.accessioned2024-02-20T13:02:39Z
dc.date.available2024-02-20T13:02:39Z
dc.date.issued2023-08-11
dc.description.abstractHuman T-cell lymphotropic virus type 1 (HTLV-1) prevalence in Portugal is low and mainly affects immigrants from endemic areas where human immunodeficiency virus (HIV) infection represents a public health problem. Despite the majority of HTLV-1-infected individuals remains asymptomatic, severe pathologies may develop after prolonged viral persistence, namely an aggressive form of leukemia. An increased mortality rate and faster progression to death is often related to HTLV-1/HIV coinfection. Nevertheless, studies showed that some antiretrovirals used in HIV treatment lead to a positive immune response against HTLV-1. This study aimed to analyze epidemiological and clinical data, and to assess the diversity of HTLV-1 strains circulating in infected residents diagnosed in the Portuguese national reference laboratory between 2010 and 2021. Long terminal repeat and env proviral sequences derived from 20 individuals were used to generate phylogenetic trees along with multiples reference sequences from different geographic origins retrieved from the database. Three samples belong to Portuguese natives and 17 belong to immigrants: 15 from several countries of Africa, 1 from South America, and 1 from Europe; 6 patients (30%, mean age 40.3 years) showed HTLV-1-related diseases, and 6 (30%, mean age 45.2 years) were coinfected with HIV/AIDS. The results show that the Cosmopolitan subtype is circulating in Portugal, with 10 sequences being classified as subgroup A, that include Portuguese and natives from S. Tomé and Príncipe with a mean age of 39.4 years, and 10 sequences that segregated into the Senegal cluster derived from natives born in Guinea-Bissau with a mean age of 43.5 years. A high proportion of HTLV-1-related diseases and HIV/AIDS coinfection was observed. Risk behavior practices and the absence of specific control measures, including diagnostic and treatment, may contribute to a silent dissemination of a broad diversity of HTLV-1 strains and, therefore, the increased rate of progression to debilitating diseases. In this manner, an early diagnostic and a molecular surveillance of HTLV-1 transmission remains necessary in Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAIDS Res Hum Retroviruses. 2023 Aug 11. doi: 10.1089/AID.2023.0026. Online ahead of printpt_PT
dc.identifier.doi10.1089/AID.2023.0026pt_PT
dc.identifier.issn1931-8405
dc.identifier.urihttp://hdl.handle.net/10400.18/9127
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebertpt_PT
dc.relation.publisherversionhttps://www.liebertpub.com/doi/10.1089/aid.2023.0026pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectHTLV-1apt_PT
dc.subjectLTR and Env Sequencingpt_PT
dc.subjectGeographic Originpt_PT
dc.subjectSubgroupspt_PT
dc.subjectDiversitypt_PT
dc.subjectHIV Infectionpt_PT
dc.subjectHuman Immunodeficiency Viruspt_PT
dc.subjectHuman T-lymphotropic Virus Type 1pt_PT
dc.subjectInfecções Sexualmente Transmissíveispt_PT
dc.subjectPortugalpt_PT
dc.titleDiversity of Human T-Lymphotropic Virus Type 1 Cosmopolitan Subtype (HTLV-1a) Circulating in Infected Residents in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAIDS Research and Human Retrovirusespt_PT
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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