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Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy

2019-09-27Journal article Restricted access
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dc.contributor.authorSmpokou, Evangelia-Theano
dc.contributor.authorGonzález-Quiroz, Marvin
dc.contributor.authorMartins, Carla
dc.contributor.authorAlvito, Paula
dc.contributor.authorLe Blond, Jennifer
dc.contributor.authorGlaser, Jason
dc.contributor.authorAragón, Aurora
dc.contributor.authorWesseling, Catharina
dc.contributor.authorNitsch, Dorothea
dc.contributor.authorPearce, Neil
dc.contributor.authorNorman, Jill
dc.contributor.authorLindh, Christian
dc.contributor.authorMorton, Jackie
dc.contributor.authorCaplin, Ben
dc.date.accessioned2020-04-23T15:57:47Z
dc.date.available2020-04-23T15:57:47Z
dc.date.issued2019-09-27
dc.descriptionThe authors are grateful to the participants of the study, the study team in Nicaragua for sample collection and preparation and all those who contributed with ideas and the analyses of samples, Kate Jones, Elizabeth Leese, James Staff, Howard Mason and Shahwaiz Iqbal from HSE, Buxton, UK, Moosa Faniband from Lund University, Sweden, and Kristina Jakobsson from University of Gothenburg, Sweden.pt_PT
dc.description.abstractObjectives: There is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months and decline in kidney function over 2 years. Methods: Urine samples collected at baseline (pre-sugarcane harvest) and the first 6 month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (aluminium, total arsenic, cadmium, chromium, cobalt, copper, lead, manganese, mercury, selenium, silicon and strontium) were analysed by inductively coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-dichlorophenoxyacetic acid, 3-phenoxybenzoic acid, 4-fluoro-3-phenoxybenzoic acid, chloro-3,3,3-trifluoro-1-propen-1-yl-2,2-dimethylcyclopropanecarboxylic acid, cis/trans 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, ethylenethiourea, glyphosate, 4-chloro-2-methylphenoxy acetic acid, 3-hydroxy-pyrimetanil, 5-hydroxytiabendazole, hydroxy-tebuconazole and 3,5,6-trichloro-2-pyridinol) and two mycotoxins (ochratoxin A (OTA) and citrinin (CIT)) were analysed by liquid chromatography coupled-mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable vs declining kidney function) were examined. Results: Elevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection. Conclusions: The tested metals, metalloids, pesticides and mycotoxins were not associated with loss of kidney function in participants at-risk of MeN.pt_PT
dc.description.sponsorshipThis study was supported by the Colt Foundation (Grant number CF/03/14 and through a PhD fellowship awarded to ETS). Additional support was received from the Dutch National Postcode Lottery providing additional funding through Solidaridad. Thanks are due for the financial support to CESAM (UID/AMB/50017/2019), to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOccup Environ Med . 2019 Dec;76(12):920-926. doi: 10.1136/oemed-2019-105772. Epub 2019 Sep 27pt_PT
dc.identifier.doi10.1136/oemed-2019-105772pt_PT
dc.identifier.issn1351-0711
dc.identifier.urihttp://hdl.handle.net/10400.18/6494
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Group/ Royal College of Physicians of London, Faculty of Occupational Medicinept_PT
dc.relation.publisherversionhttps://oem.bmj.com/content/76/12/920.longpt_PT
dc.subjectChronic Kidney Disease of Unknown Origin (CKDu)pt_PT
dc.subjectEnvironmental Toxinspt_PT
dc.subjectMesoamerican Nephropathy (MeN)pt_PT
dc.subjectNephrotoxicitypt_PT
dc.subjectPesticidespt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectToxicologiapt_PT
dc.subjectSaúde Humanapt_PT
dc.titleEnvironmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage926pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage920pt_PT
oaire.citation.titleOccupational and Environmental Medicinept_PT
oaire.citation.volume76pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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