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Joint effect of heat and air pollution on mortality in 620 cities of 36 countries

dc.contributor.authorStafoggia, Massimo
dc.contributor.authorMichelozzi, Paola
dc.contributor.authorSchneider, Alexandra
dc.contributor.authorArmstrong, Ben
dc.contributor.authorScortichini, Matteo
dc.contributor.authorRai, Masna
dc.contributor.authorAchilleos, Souzana
dc.contributor.authorAlahmad, Barrak
dc.contributor.authorAnalitis, Antonis
dc.contributor.authorÅström, Christofer
dc.contributor.authorBell, Michelle L.
dc.contributor.authorCalleja, Neville
dc.contributor.authorKrage Carlsen, Hanne
dc.contributor.authorCarrasco, Gabriel
dc.contributor.authorPaul Cauchi, John
dc.contributor.authorDSZS Coelho, Micheline
dc.contributor.authorCorrea, Patricia M.
dc.contributor.authorDiaz, Magali H.
dc.contributor.authorEntezari, Alireza
dc.contributor.authorForsberg, Bertil
dc.contributor.authorGarland, Rebecca M.
dc.contributor.authorLeon Guo, Yue
dc.contributor.authorGuo, Yuming
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorHolobaca, Iulian H.
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorKan, Haidong
dc.contributor.authorKatsouyanni, Klea
dc.contributor.authorKim, Ho
dc.contributor.authorKyselý, Jan
dc.contributor.authorLavigne, Eric
dc.contributor.authorLee, Whanhee
dc.contributor.authorLi, Shanshan
dc.contributor.authorMaasikmets, Marek
dc.contributor.authorMadureira, Joana
dc.contributor.authorMayvaneh, Fatemeh
dc.contributor.authorFook Sheng Ng, Chris
dc.contributor.authorNunes, Baltazar
dc.contributor.authorOrru, Hans
dc.contributor.authorV Ortega, Nicolás
dc.contributor.authorOsorio, Samuel
dc.contributor.authorPalomares, Alfonso D.L.
dc.contributor.authorPan, Shih-Chun
dc.contributor.authorPascal, Mathilde
dc.contributor.authorRagettli, Martina S
dc.contributor.authorRao, Shilpa
dc.contributor.authorRaz, Raanan
dc.contributor.authorRoye, Dominic
dc.contributor.authorRyti, Niilo
dc.contributor.authorHN Saldiva, Paulo
dc.contributor.authorSamoli, Evangelia
dc.contributor.authorSchwartz, Joel
dc.contributor.authorScovronick, Noah
dc.contributor.authorSera, Francesco
dc.contributor.authorTobias, Aurelio
dc.contributor.authorTong, Shilu
dc.contributor.authorDLC Valencia, César
dc.contributor.authorMaria Vicedo-Cabrera, Ana
dc.contributor.authorUrban, Aleš
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorBreitner, Susanne
dc.contributor.authorde' Donato, Francesca K.
dc.date.accessioned2024-02-20T15:16:41Z
dc.date.available2024-02-20T15:16:41Z
dc.date.issued2023-10-10
dc.description.abstractBackground: The epidemiological evidence on the interaction between heat and ambient air pollution on mortality is still inconsistent. Objectives: To investigate the interaction between heat and ambient air pollution on daily mortality in a large dataset of 620 cities from 36 countries. Methods: We used daily data on all-cause mortality, air temperature, particulate matter ≤ 10 μm (PM10), PM ≤ 2.5 μm (PM2.5), nitrogen dioxide (NO2), and ozone (O3) from 620 cities in 36 countries in the period 1995-2020. We restricted the analysis to the six consecutive warmest months in each city. City-specific data were analysed with over-dispersed Poisson regression models, followed by a multilevel random-effects meta-analysis. The joint association between air temperature and air pollutants was modelled with product terms between non-linear functions for air temperature and linear functions for air pollutants. Results: We analyzed 22,630,598 deaths. An increase in mean temperature from the 75th to the 99th percentile of city-specific distributions was associated with an average 8.9 % (95 % confidence interval: 7.1 %, 10.7 %) mortality increment, ranging between 5.3 % (3.8 %, 6.9 %) and 12.8 % (8.7 %, 17.0 %), when daily PM10 was equal to 10 or 90 μg/m3, respectively. Corresponding estimates when daily O3 concentrations were 40 or 160 μg/m3 were 2.9 % (1.1 %, 4.7 %) and 12.5 % (6.9 %, 18.5 %), respectively. Similarly, a 10 μg/m3 increment in PM10 was associated with a 0.54 % (0.10 %, 0.98 %) and 1.21 % (0.69 %, 1.72 %) increase in mortality when daily air temperature was set to the 1st and 99th city-specific percentiles, respectively. Corresponding mortality estimate for O3 across these temperature percentiles were 0.00 % (-0.44 %, 0.44 %) and 0.53 % (0.38 %, 0.68 %). Similar effect modification results, although slightly weaker, were found for PM2.5 and NO2. Conclusions: Suggestive evidence of effect modification between air temperature and air pollutants on mortality during the warm period was found in a global dataset of 620 cities.pt_PT
dc.description.sponsorshipFunding: Massimo Stafoggia, Francesca K. de’ Donato, Masna Rai and Alexandra Schneider were partially supported by the European Union’s Horizon 2020 Project Exhaustion (Grant ID: 820655). Jan Kyselý and Aleš Urban were supported by the Czech Science Foundation project (22-24920S). Joana Madureira was supported by the Fundação para a Ciência e a Tecnologia (FCT) (grant SFRH/BPD/115112/2016). Masahiro Hashizume was supported by the Japan Science and Technology Agency (JST) as part of SICORP, Grant Number JPMJSC20E4. Noah Scovronick was supported by the NIEHS-funded HERCULES Center (P30ES019776). South African Data were provided by Statistics South Africa, which did not have any role in conducting the study. Antonio Gasparrini was supported by the Medical Research Council-UK (Grants ID: MR/V034162/1 and MR/R013349/1), the Natural Environment Research Council UK (Grant ID: NE/R009384/1), and the European Union’s Horizon 2020 Project Exhaustion (Grant ID: 820655).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Int. 2023 Nov:181:108258. doi: 10.1016/j.envint.2023.108258. Epub 2023 Oct 10. Meta-Analysispt_PT
dc.identifier.doi10.1016/j.envint.2023.108258pt_PT
dc.identifier.issn0160-4120
dc.identifier.urihttp://hdl.handle.net/10400.18/9130
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0160412023005317?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMortalitypt_PT
dc.subjectAir Temperaturept_PT
dc.subjectAir Pollutionpt_PT
dc.subjectMCCpt_PT
dc.subjectEffect Modificationpt_PT
dc.subjectEpidemiologypt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectAvaliação do Impacte em Saúdept_PT
dc.titleJoint effect of heat and air pollution on mortality in 620 cities of 36 countriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/820655/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.citation.startPage108258pt_PT
oaire.citation.titleEnvironment Internationalpt_PT
oaire.citation.volume181pt_PT
oaire.fundingStreamH2020
person.familyNameNunes
person.givenNameBaltazar
person.identifier.ciencia-idAB11-AD48-A8DF
person.identifier.orcid0000-0001-6230-7209
person.identifier.scopus-author-id9133723200
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverybe4efa0d-49df-4a93-bfdd-b76d9f7bf492
relation.isProjectOfPublication59609b8b-2750-43e0-8fe9-155a4915a572
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