Repository logo
 
Publication

Microglial innate memory and epigenetic reprogramming in neurological disorders

2020-12-09Journal article Restricted access
Simple item page
dc.contributor.authorMartins-Ferreira, Ricardo
dc.contributor.authorLeal, Bárbara
dc.contributor.authorCosta, Paulo
dc.contributor.authorBallestar, Esteban
dc.date.accessioned2021-03-26T11:54:22Z
dc.date.available2021-03-26T11:54:22Z
dc.date.issued2020-12-09
dc.description.abstractMicroglia are myeloid-derived cells recognized as brain-resident macrophages. They act as the first and main line of immune defense in the central nervous system (CNS). Microglia have high phenotypic plasticity and are essential for regulating healthy brain homeostasis, and their dysregulation underlies the onset and progression of several CNS pathologies through impaired inflammatory responses. Aberrant microglial activation, following an inflammatory insult, is associated with epigenetic dysregulation in various CNS pathologies. Emerging data suggest that certain stimuli to myeloid cells determine enhanced or attenuated responses to subsequent stimuli. These phenomena, generally termed innate immune memory (IIM), are highly dependent on epigenetic reprogramming. Microglial priming has been reported in several neurological diseases and corresponds to a state of increased permissiveness or exacerbated response, promoted by continuous exposure to a chronic pro-inflammatory environment. In this article, we provide extensive evidence of these epigenetic-mediated phenomena under neurological conditions and discuss their contribution to pathogenesis and their clinical implications, including those concerning potential novel therapeutic approaches.pt_PT
dc.description.abstractHighlights: Microglia are crucial for the central nervous system’s development and function; Epigenetics mediate the establishment of the homeostatic microglia phenotype; Neurological diseases associate with microglia-specific altered expression profiles; Microglia can be pre-conditioned through epigenetic-driven innate immune memory.pt_PT
dc.description.sponsorshipE.B. is funded by the Spanish Ministry of Science and Innovation (grant number SAF2017- 88086-R; AEI/FEDER, UE). This work was supported by a BICE Tecnifar Grant. R.M.-F was funded by an FCT (Fundaçao ˜ para a Ciˆencia e Tecnologia) fellowship (grant number SFRH/BD/137900/2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationProg Neurobiol. 2020 Dec 9;101971. doi: 10.1016/j.pneurobio.2020.101971. Online ahead of print.pt_PT
dc.identifier.doi10.1016/j.pneurobio.2020.101971pt_PT
dc.identifier.issn0301-0082
dc.identifier.urihttp://hdl.handle.net/10400.18/7605
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEpigenetic regulation of signalling pathways in MTLE-HS and its impact on epileptogenesis
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0301008220302264?via%3Dihubpt_PT
dc.subjectMicrogliapt_PT
dc.subjectDNA Methylationpt_PT
dc.subjectNeurological Diseasespt_PT
dc.subjectEpigeneticspt_PT
dc.subjectEpigeneticspt_PT
dc.subjectInnate Immunitypt_PT
dc.subjectHistone Modificationspt_PT
dc.subjectInnate Immune Memorypt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleMicroglial innate memory and epigenetic reprogramming in neurological disorderspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpigenetic regulation of signalling pathways in MTLE-HS and its impact on epileptogenesis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F137900%2F2018/PT
oaire.citation.startPage101971pt_PT
oaire.citation.titleProgress in Neurobiologypt_PT
oaire.fundingStreamPOR_NORTE
person.familyNameLeal
person.familyNamede Castro Pinho e Costa
person.familyNameBallestar
person.givenNameBárbara
person.givenNamePaulo Manuel
person.givenNameEsteban
person.identifierB-4392-2008
person.identifier203582
person.identifier.ciencia-id1511-1F97-9455
person.identifier.ciencia-id6A17-F7BE-D4BC
person.identifier.orcid0000-0003-0936-4719
person.identifier.orcid0000-0001-6125-7000
person.identifier.orcid0000-0002-1400-2440
person.identifier.scopus-author-id35170382000
person.identifier.scopus-author-id14023271500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc0479ea5-0fe7-4e08-85c1-3703b33359b1
relation.isAuthorOfPublicatione7de4cb4-90e1-4815-9896-56ea697310f9
relation.isAuthorOfPublication7deaf355-945c-451d-8dae-51ce6c3636b5
relation.isAuthorOfPublication.latestForDiscovery7deaf355-945c-451d-8dae-51ce6c3636b5
relation.isProjectOfPublicatione75fa6c9-c027-4acb-9c30-9ef23fe9eb5d
relation.isProjectOfPublication.latestForDiscoverye75fa6c9-c027-4acb-9c30-9ef23fe9eb5d

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Martins-Ferreira 2020 - Microglial innate memory and epigenetic reprogramming in neurological disorders.pdf
Size:
6.02 MB
Format:
Adobe Portable Document Format
Download

Collections

DGH - Artigos em revistas internacionais