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Biofilms within the human body and its clinical implications

2018-03-01Conference object Restricted access
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dc.contributor.authorJordão, Luísa
dc.contributor.authorSubtil, João
dc.contributor.authorLavado, Paula
dc.contributor.authorRodrigues, João
dc.contributor.authorReis, Lúcia
dc.contributor.authorFaria, Isabel
dc.contributor.authorPessanha, Maria Ana
dc.date.accessioned2019-02-06T17:33:35Z
dc.date.available2022-12-31T01:30:30Z
dc.date.issued2018-03-01
dc.description.abstractBiofilms with medical implications could be find on medical devices or on organs. Here we discuss the results obtained in two studies one associated with an organ (adenoid) and another associated with a medical device (central venous catheters- CVC). In the first study, we evaluate the association between biofilm assembly on adenoids and the incidence of recurrent infections in a paediatric population comparing adenoid samples from adenoidectomy groups with and without infectious indication. Biofilms were present in 27.4% of the adenoid samples. For H. influenzae, S. aureus, S. pyogenes, S. pneumococcus and M. catarrhalis, no association was found between ability to assemble biofilms in vitro and the presence of biofilms on adenoids, and the same was found for antibiotic resistance. The most isolated bacterium was H. influenzae that revealed after further characterization to be non-typeable (NT). No statistical difference was found on biofilm presence between the two groups, infectious versus non-infectious diagnosis. The same was true for biofilm assembling ability of bacteria found on adenoid surface and core. As in other studies, we did not find a correlation between biofilm formation and susceptibility or resistance to antibiotics and this raise the question of the importance of biofilms on the pathogenesis of infectious diseases. In the second study, we explore the relation between the presence of biofilms on central venous catheters and central venous catheter-related bloodstream infection (CRBSI). Our preliminary results (relative to data collected over 10 months) show that Staphylococci, either coagulase negative or positive, are major etiologic agents of this healthcare associated infection.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5717
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectBiofilmspt_PT
dc.subjectAdenoidpt_PT
dc.subjectHAIpt_PT
dc.subjectCVCpt_PT
dc.subjectAgentes Microbianos e Ambientept_PT
dc.titleBiofilms within the human body and its clinical implicationspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBelgrado, Sérviapt_PT
oaire.citation.title7th iPROMEDAI S&T Meeting &T and Focus Group meetings, 27 February-1 March 2018pt_PT
rcaap.embargofctExistem resultados de trabalhos em curso que ainda não estão concluídos e/ou publicados.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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