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Bronchoalveolar lavage proteomics in patients with suspected lung cancer

2017-02-07Journal article Open access
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dc.contributor.authorCarvalho, A.S.
dc.contributor.authorCuco, C.M.
dc.contributor.authorLavareda, C.
dc.contributor.authorMiguel, F.
dc.contributor.authorVentura, M.
dc.contributor.authorAlmeida, S.
dc.contributor.authorPinto, P.
dc.contributor.authorde Abreu, T.T.
dc.contributor.authorRodrigues, L.V.
dc.contributor.authorSeixas, S.
dc.contributor.authorBárbara, C.
dc.contributor.authorAzkargorta, M.
dc.contributor.authorElortza, F.
dc.contributor.authorSemedo, J.
dc.contributor.authorField, J.K.
dc.contributor.authorMota, L.
dc.contributor.authorMatthiesen, R.
dc.date.accessioned2017-11-03T15:17:19Z
dc.date.available2017-11-03T15:17:19Z
dc.date.issued2017-02-07
dc.description.abstractLung cancer configures as one of the deadliest types of cancer. The future implementation of early screening methods such as exhaled breath condensate analysis and low dose computed tomography (CT) as an alternative to current chest imaging based screening will lead to an increased burden on bronchoscopy units. New approaches for improvement of diagnosis in bronchoscopy units, regarding patient management, are likely to have clinical impact in the future. Diagnostic approaches to address mortality of lung cancer include improved early detection and stratification of the cancers according to its prognosis and further response to drug treatment. In this study, we performed a detailed mass spectrometry based proteome analysis of acellular bronchoalveolar lavage (BAL) fluid samples on an observational prospective cohort consisting of 90 suspected lung cancer cases which were followed during two years. The thirteen new lung cancer cases diagnosed during the follow up time period clustered, based on liquid chromatography-mass spectrometry (LC-MS) data, with lung cancer cases at the time of BAL collection. Hundred and thirty-tree potential biomarkers were identified showing significantly differential expression when comparing lung cancer versus non-lung cancer. The regulated biomarkers showed a large overlap with biomarkers detected in tissue samples.pt_PT
dc.description.sponsorshipAll experiments including MS analysis were supported by Fundação para a Ciência e Tecnologia project EXPL/ DTP-PIC/0616/2013. RM is supported by FCT investigator program 2012 (IF/01002/2012). ASC is supported by grant SFRH/BPD/85569/2012 funded by Fundação para a Ciência e Tecnologia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2017 Feb 7;7:42190. doi: 10.1038/srep42190.pt_PT
dc.identifier.doi10.1038/srep42190pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.18/4803
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationIdentificação global por Espectrometria de Massa de aspirados bronquiais: visando modificações específicas do cancro do pulmão.
dc.relation.publisherversionhttps://www.nature.com/articles/srep42190pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLung Cancerpt_PT
dc.subjectProteomicspt_PT
dc.titleBronchoalveolar lavage proteomics in patients with suspected lung cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIdentificação global por Espectrometria de Massa de aspirados bronquiais: visando modificações específicas do cancro do pulmão.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FDTP-PIC%2F0616%2F2013/PT
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicatione580f746-a5e9-4b40-90b8-99c2f308c44a
relation.isProjectOfPublication.latestForDiscoverye580f746-a5e9-4b40-90b8-99c2f308c44a

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